758680-79-4

Basic information

• Product Name: cefotaxime
• Synonyms: cefotaxime
• CAS NO: 758680-79-4
• Molecular Weight: 455.472
• Mol File: 758680-79-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: cefotaxime(CAS DataBase Reference)
• NIST Chemistry Reference: cefotaxime(758680-79-4)
• EPA Substance Registry System: cefotaxime(758680-79-4)

Safety Data

• Hazardous Substances Data: 758680-79-4(Hazardous Substances Data)

Upstream product

• 94088-75-2 2-(2-amino-1,3-thiazol-4-yl)-1-(1,3-benzothiazol-2-ylsulfanyl)-2-(methoxyimino)ethan-1-one 
• 108260-00-0 7-aminocephalosporanic acid 

Downstream Products

• 91868-79-0 2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetic acid 
• 65052-63-3 desacetoxycefotaxime 
• 66340-28-1 desacetylcefotaxime 
• 66340-33-8 desacetylcefotaxime lactone 
• 108260-00-0 7-aminocephalosporanic acid 

Relevant articles and documents

Preparation method for improving product quality of cefotaxime sodium

The invention provides a preparation method for improving the product quality of cefotaxime sodium. The preparation method is characterized in that after pure water and organic alcohol are added into a reaction solvent, 7-aminocephalosporanic acid is dissolved under a neutral/slightly alkaline condition; then an impurity layer is separated; then a condensation reaction is performed with 2-(2-amino-4-thiazolyl)-2-methoxyiminoacetic to generate cefotaxime; a cefotaxime water solution obtained through extraction is directly added into an alcoholic solution of sodium acetate or sodium iso-octoate for a salt forming reaction without crystallization; decarbonization and sterile filtration are performed; then crystallization is performed by utilizing the solvent to obtain the target product cefotaxime sodium. The cefotaxime sodium prepared by the method provided by the invention is high in purity and good in yield.