763120-58-7 Usage
Description
1H-PYRAZOLE-4-BORONIC ACID is an organic compound with the chemical formula C3H4BNO2 and is characterized by its white powder appearance. It is a boronic acid derivative of the pyrazole family, which is known for its versatile chemical properties and potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
1H-PYRAZOLE-4-BORONIC ACID is used as a reagent for the preparation of dimethyl-dihydroquinazolinones, which serve as protein kinase C-θ (PKCθ) inhibitors. PKCθ is a key enzyme involved in various cellular processes, and its inhibition can be beneficial in treating certain diseases and conditions.
1H-PYRAZOLE-4-BORONIC ACID is also used as a reagent for the preparation of dihydroquinazolinones, which act as inhibitors of Trypanosoma brucei. This parasite is responsible for African trypanosomiasis, also known as sleeping sickness, and the development of effective inhibitors is crucial for the treatment of this disease.
Check Digit Verification of cas no
The CAS Registry Mumber 763120-58-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,6,3,1,2 and 0 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 763120-58:
(8*7)+(7*6)+(6*3)+(5*1)+(4*2)+(3*0)+(2*5)+(1*8)=147
147 % 10 = 7
So 763120-58-7 is a valid CAS Registry Number.
InChI:InChI=1/C3H5BN2O2/c7-4(8)3-1-5-6-2-3/h1-2,7-8H,(H,5,6)
763120-58-7Relevant articles and documents
Preparation method of nitrogen unsubstituted pyrazole and indazole boric acid
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Paragraph 0029-0031; 0034-0036, (2020/01/12)
The invention discloses a method for preparing nitrogen unsubstituted pyrazole and indazole boric acid. Nitrogen unsubstituted halogenated pyrazole and a derivative thereof, or nitrogen unsubstitutedhalogenated indazole and a derivative of the nitrogen unsubstituted halogenated indazole react with triisopropylchlorosilane in an organic solvent to generate a triisopropylsilyl protected halogenatedpyrazole or halogenated indazole compound, then a lithium-bromine exchange reaction is carried out with n-butyl lithium, a borate is added to introduce boron atoms, and the nitrogen unsubstituted pyrazole or indazole boric acid is obtained in high yield after hydrolysis.