76370-06-4

Basic information

• Product Name: N-Boc-(N-Me)Phe-(N-Me)Phe-OMe
• Synonyms: N-Boc-(N-Me)Phe-(N-Me)Phe-OMe
• CAS NO: 76370-06-4
• Molecular Weight: 454.566
• Mol File: 76370-06-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-Boc-(N-Me)Phe-(N-Me)Phe-OMe(CAS DataBase Reference)
• NIST Chemistry Reference: N-Boc-(N-Me)Phe-(N-Me)Phe-OMe(76370-06-4)
• EPA Substance Registry System: N-Boc-(N-Me)Phe-(N-Me)Phe-OMe(76370-06-4)

Safety Data

• Hazardous Substances Data: 76370-06-4(Hazardous Substances Data)

Upstream product

• 37553-65-4 Boc-N-Me-Phe-OH 
• 66866-67-9 N-methyl-L-phenylalanine hydrochloride 

Downstream Products

• 1471519-96-6 N-Boc-Pro-(N-Me)Phe-(N-Me)Phe-OMe 
• 1471520-06-5 N-Boc-Tyr-Pro-(N-Me)Phe-(N-Me)Phe-OMe 
• 1471520-16-7 N-Boc-Tyr-Pro-(N-Me)Phe-(N-Me)Phe-NH(CH₂)₂OH 
• 1471520-31-6 TFA·Tyr-Pro-(N-Me)Phe-(N-Me)Phe-NH(CH₂)₂OH 
• 1071228-42-6 C₂₀H₂₈N₂O 

Relevant articles and documents

Hybrid peptides endomophin-2/DAMGO: Design, synthesis and biological evaluation

Endomorphin-2 [Tyr-Pro-Phe-Phe-NH2] and DAMGO [Tyr-D-Ala-Gly-(N-Me)Phe-Gly-ol] are natural (EM2) and synthetic (DAMGO) opioid peptides both selective for μ opioid receptor with high analgesic activity. In this work we report synthesis, in vitro and in vivo biological evaluation of five new hybrid EM2/DAMGO analogues, with the aim to obtain compounds with high affinity at μ-opioid receptor, high activity in animal nociception tests (hot plate and tail flick) and improved enzymatic stability. Double N-methylation on both Phe residues and C-terminal ethanolamide led to analogue 6e, which possesses a good in vitro μ affinity (Kiμ = 34 nM), combined with a remarkable in vivo antinociceptive activity.