76403-35-5Relevant articles and documents
Synthesis and evaluation of a new series of Neuropeptide S receptor antagonists
Melamed, Jeffrey Y.,Zartman, Amy E.,Kett, Nathan R.,Gotter, Anthony L.,Uebele, Victor N.,Reiss, Duane R.,Condra, Cindra L.,Fandozzi, Christine,Lubbers, Laura S.,Rowe, Blake A.,McGaughey, Georgia B.,Henault, Martin,Stocco, Rino,Renger, John J.,Hartman, George D.,Bilodeau, Mark T.,Trotter, B. Wesley
scheme or table, p. 4700 - 4703 (2010/10/02)
Administration of Neuropeptide S (NPS) has been shown to produce arousal, that is, independent of novelty and to induce wakefulness by suppressing all stages of sleep, as demonstrated by EEG recordings in rat. Medicinal chemistry efforts have identified a quinolinone class of potent NPSR antagonists that readily cross the blood-brain barrier. We detail here optimization efforts resulting in the identification of a potent NPSR antagonist which dose-dependently and specifically inhibited 125I-NPS binding in the CNS when administered to rats.
Synthesis of alkaloid analogues from α-amino acids by one-pot radical decarboxylation/alkylation
Boto, Alicia,De Leon, Yolanda,Gallardo, Juan Antonio,Hernandez, Rosendo
, p. 3461 - 3468 (2007/10/03)
A mild, one-pot methodology to obtain α-substituted nitrogen heterocycles from commercial amino acids is reported. This versatile procedure has been applied to the synthesis of different alkaloid analogues in good to excellent yields. Wiley-VCH Verlag GmbH & Co. KGaA, 2005.
