76579-44-7

Basic information

• Product Name: 1-[4-(2,2,2-trifluoroethoxy)phenyl]ethanone
• Synonyms: 1-[4-(2,2,2-trifluoroethoxy)phenyl]ethanone
• CAS NO: 76579-44-7
• Molecular Formula: C₁₀H₉F₃O₂
• Molecular Weight: 218.1724696
• Mol File: 76579-44-7.mol
• Article Data: 10

Chemical Properties

• Melting Point: 72-73 °C
• Boiling Point: 256.4±40.0 °C(Predicted)
• Appearance: /
• Density: 1.226±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1-[4-(2,2,2-trifluoroethoxy)phenyl]ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[4-(2,2,2-trifluoroethoxy)phenyl]ethanone(76579-44-7)
• EPA Substance Registry System: 1-[4-(2,2,2-trifluoroethoxy)phenyl]ethanone(76579-44-7)

Safety Data

• Hazardous Substances Data: 76579-44-7(Hazardous Substances Data)

Usage

Type of compound

Ketone

Structure

Contains a phenyl group substituted with a trifluoroethoxy moiety

Common use

Building block in organic synthesis

Applications

Production of pharmaceuticals and agrochemicals

Reactions

Utilized in nucleophilic additions and substitution reactions

Potential applications

Medicinal chemistry and drug discovery

Ability

To modulate biological activity and potential pharmacological properties

Importance

Versatile and significant compound with various industrial and research applications

Upstream product

• 420-87-1 sodium 2,2,2-trifluoroethanolate 
• 100-19-6 (4-nitrophenyl)ethanone 
• 25236-64-0 2,2,2-trifluoroethyl methanesulfonate 
• 99-93-4 4-Hydroxyacetophenone 
• 99-90-1 para-bromoacetophenone 
• 75-89-8 2,2,2-trifluoroethanol 
• 149104-90-5 4-acetylphenylboronic acid 
• 99-91-2 para-chloroacetophenone 
• 67-56-1 methanol 
• 433-06-7 2,2,2-Trifluoroethyl p-toluenesulfonate 

Downstream Products

• 129560-99-2 4-(2,2,2-trifluoroethoxy)phenol 
• 128140-38-5 4-Pentyl-cyclohexanecarboxylic acid 4-(2,2,2-trifluoro-ethoxy)-phenyl ester 
• 128140-39-6 4'-Pentyl-bicyclohexyl-4-carboxylic acid 4-(2,2,2-trifluoro-ethoxy)-phenyl ester 

Relevant articles and documents

CARBAMATE DERIVATIVES AND USES THEREOF

The present disclosure relates to compounds of Formula (I): and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inflammatory, autoinflammatory and autoimmune diseases and cancers.

Palladium-Catalyzed 2,2,2-Trifluoroethoxylation of Aromatic and Heteroaromatic Chlorides Utilizing Borate Salt and the Synthesis of a Trifluoro Analogue of Sildenafil

A simple and convenient method was developed for the introduction of a 2,2,2-trifluoroethoxy group to various aromatic and heteroaromatic systems. The novel process utilizes aromatic chlorides as substrates, and tetrakis(2,2,2-trifluoroethoxy) borate salt as an inexpensive and readily available fluoroalkoxy source in a palladium-catalyzed cross-coupling reaction. The power of the developed methodology was demonstrated in the synthesis of a fluorous derivative of Sildenafil.

Well-defined copper(I) fluoroalkoxide complexes for trifluoroethoxylation of aryl and heteroaryl bromides

Copper(I) fluoroalkoxide complexes bearing dinitrogen ligands were synthesized and the structure and reactivity of the complexes toward trifluoroethoxylation, pentafluoropropoxylation, and tetrafluoropropoxylation of aryl and heteroaryl bromides were investigated. Efficiency drive: A series of copper(I) fluoroalkoxide complexes bearing N,N ligands have been prepared and structurally characterized. These well-defined complexes serve as efficient reagents for the fluoroalkoxylation of aryl and heteroaryl bromides to produce a wide range of trifluoroethyl, pentafluoropropyl, and tetrafluoropropyl (hetero)aryl ethers in good to excellent yields.