765917-07-5

Basic information

• Product Name: 3-(2,4-difluorophenyl)-5-(4-fluoro-3-trifluoromethylphenyl)-[1,2,4]triazine
• CAS NO: 765917-07-5
• Molecular Weight: 355.242
• Mol File: 765917-07-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(2,4-difluorophenyl)-5-(4-fluoro-3-trifluoromethylphenyl)-[1,2,4]triazine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2,4-difluorophenyl)-5-(4-fluoro-3-trifluoromethylphenyl)-[1,2,4]triazine(765917-07-5)
• EPA Substance Registry System: 3-(2,4-difluorophenyl)-5-(4-fluoro-3-trifluoromethylphenyl)-[1,2,4]triazine(765917-07-5)

Safety Data

• Hazardous Substances Data: 765917-07-5(Hazardous Substances Data)

Upstream product

• 765917-04-2 (4-fluoro-3-trifluoromethylphenyl)-oxoacetaldehyde 
• 175276-92-3 2,4-difluorobenzene-1-carbothioamide 

Downstream Products

• 765917-23-5 3-(2,4-difluorophenyl)-5-(4-fluoro-3-trifluoromethylphenyl)-[1,2,4]triazine 1-oxide 

Relevant articles and documents

5-Phenyl[1,2,4]triazines as ligands for GABA-A alpha2/alpha3 receptors for treating anxiety or depression

The present invention provides a compound of formula I, or an N-oxide thereof or a pharmaceutically acceptable salt thereof: wherein X1 represents hydrogen, halogen, C1-6 alkyl, trifluoromethyl or C1-6 alkoxy; X2 represents hydrogen or halogen; Z represents hydrogen, halogen, cyano, cyanomethyl, trifluoromethyl, nitro, hydroxy, hydroxy(C1-6)alkyl, C1-6 alkoxy, C1-6 alkoxy(C1-6)alkyl, trifluoromethoxy, trifluoromethylthio, trifluoromethanesulfinyl, formyl, C2-6 alkoxycarbonyl, oxopyrrolidinyl, or an optionally substituted aryl, heteroaryl or heteroaryl(C1-6)alkoxy group; and R1 represents aryl or heteroaryl, either of which groups may be optionally substituted; pharmaceutical compositions comprising it, its use in therapy and methods of treatment of anxiety and/or depression using it.