7661-12-3

Basic information

• Product Name: Propanamide, 3-bromo-N-(4-chlorophenyl)-
• CAS NO: 7661-12-3
• Molecular Formula: C9H9BrClNO
• Molecular Weight: 262.534
• Mol File: 7661-12-3.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Propanamide, 3-bromo-N-(4-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanamide, 3-bromo-N-(4-chlorophenyl)-(7661-12-3)
• EPA Substance Registry System: Propanamide, 3-bromo-N-(4-chlorophenyl)-(7661-12-3)

Safety Data

• Hazardous Substances Data: 7661-12-3(Hazardous Substances Data)

Upstream product

• 590-92-1 3-Bromopropionic acid 
• 106-47-8 4-chloro-aniline 
• 15486-96-1 3-Bromopropionyl chloride 

Downstream Products

• 1235866-22-4 9-O-[(3-oxo-3-p-chlorophenylamino)propyl]berberine bromide 
• 6321-64-8 2-chloro-10-phenylacridin-9(10H)-one 
• 1393643-19-0 N-hydroxy-4-{[(4-chlorophenylcarbamoylethyl)amino]methyl}benzamide 
• 1207113-86-7 C₁₈H₁₅ClF₆N₂O 

Relevant articles and documents

Arylamide as Potential Selective Inhibitor for Matrix Metalloproteinase 9 (MMP9): Design, Synthesis, Biological Evaluation, and Molecular Modeling

Previous studies have reported that compounds bearing an arylamide linked to a heterocyclic planar ring have successfully inhibited the hemopexin-like domain (PEX9) of matrix metalloproteinase 9 (MMP9). PEX9 has been suggested to be more selectively targe

Formation of acridones by ethylene extrusion in the reaction of arynes with β-lactams and dihydroquinolinones

N-Unsubstituted β-lactams react with a molecule of aryne by insertion into the amide bond to form a 2,3-dihydroquinolin-4-one, which subsequently reacts with another molecule of aryne to form an acridone by extrusion of a molecule of ethylene. 2,3-Dihydroquinolin-4-ones react under the same reaction conditions to afford identical results. This is the first example of ethylene extrusion in aryne chemistry.

Design, synthesis and prostate cancer cell-based studies of analogs of the Rho/MKL1 transcriptional pathway inhibitor, CCG-1423

We recently identified bis(amide) CCG-1423 (1) as a novel inhibitor of RhoA/C-mediated gene transcription that is capable of inhibiting invasion of PC-3 prostate cancer cells in a Matrigel model of metastasis. An initial structure-activity relationship study focusing on bioisosteric replacement of the amides and conformational restriction identified two compounds, 4g and 8, with improved selectivity for inhibition of RhoA/C-mediated gene transcription and attenuated cytotoxicity relative to 1. Both compounds were also capable of inhibiting cell invasion with equal efficacy to 1 but with less attendant cytotoxicity.