76874-79-8 Usage
General Description
2-Amino-4-Chloro-5-Thiazolecarbaldehyde is a chemical compound characterized by its incorporation of chlorine, nitrogen, sulfur, hydrogen, and carbon atoms. Given the specificity of its structure and composition, it is especially relevant in fields like chemistry, pharmacology, and material sciences. Its roles in these areas could involve being used as an analytical reagent, a foundation for synthesizing other substances, or even possibly as an intermediary in the formulation of specific pharmaceutical drugs. Just like any other chemical substance, appropriate precautions must be taken when handling 2-Amino-4-Chloro-5-Thiazolecarbaldehyde due to potential physical or health hazards. Beyond these elements, however, more specific details about the properties and functions of 2-Amino-4-Chloro-5-Thiazolecarbaldehyde are limited, owing to its specialized nature and use.
Check Digit Verification of cas no
The CAS Registry Mumber 76874-79-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,6,8,7 and 4 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 76874-79:
(7*7)+(6*6)+(5*8)+(4*7)+(3*4)+(2*7)+(1*9)=188
188 % 10 = 8
So 76874-79-8 is a valid CAS Registry Number.
InChI:InChI=1/C4H3ClN2OS/c5-3-2(1-8)9-4(6)7-3/h1H,(H2,6,7)
76874-79-8Relevant articles and documents
Tetramethylammonium Fluoride Tetrahydrate for SNAr Fluorination of 4-Chlorothiazoles at a Production Scale
Hawk, Mai Khanh,Ryan, Sarah J.,Zhang, Xin,Huang, Ping,Chen, Jing,Liu, Chuanren,Chen, Jianping,Lindsay-Scott, Peter J.,Burnett, John,White, Craig,Lu, Yu,Rizzo, John R.
, p. 1167 - 1175 (2021/05/31)
This article describes the use of tetramethylammonium fluoride tetrahydrate (TMAF·4H2O) for the large-scale preparation of a challenging 4-fluorothiazole. Commercially available TMAF·4H2O was procured on a large scale and rigorously dried by distillation with isopropyl alcohol and then dimethylformamide at elevated temperature. This method of drying provided anhydrous TMAF [TMAF (anh)] containing a 45.1 kg scale at 95-100 °C to produce 36.8 kg of 4-fluorothiazole 1b.
Preparation of 2-amino-5-formyl-4-halothiazoles
-
, (2008/06/13)
A process for the preparation of 2-amino-5-formyl-4-halothiazoles by reaction, in a first stage, of thiourea with chloroacetic or bromoacetic acid in the presence of an N,N-disubstituted formamide, followed by treatment of the reaction mixture with a phosphoric trihalide and then with water in the presence of a base.