76928-53-5

Basic information

• Product Name: 2-ethynyltetrahydro-2H-pyran
• Synonyms: 2-Ethynyltetrahydro-2H-pyran; 2H-pyran, 2-ethynyltetrahydro-
• CAS NO: 76928-53-5
• Molecular Formula: C₇H₁₀O
• Molecular Weight: 110.1537
• Mol File: 76928-53-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 138.073°C at 760 mmHg
• Flash Point: 27.363°C
• Density: 0.939g/cm³
• Vapor Pressure: 8.501mmHg at 25°C
• Refractive Index: 1.457
• CAS DataBase Reference: 2-ethynyltetrahydro-2H-pyran(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ethynyltetrahydro-2H-pyran(76928-53-5)
• EPA Substance Registry System: 2-ethynyltetrahydro-2H-pyran(76928-53-5)

Safety Data

• Hazardous Substances Data: 76928-53-5(Hazardous Substances Data)

Upstream product

• 3136-02-5 2-chlorotetrahydro-2H-pyran 
• 74-86-2 acetylene 
• 202604-25-9 (+/-)-2-(2-trimethylsilylethynyl)tetrahydropyran 
• 4301-14-8 acetylenemagnesium bromide 
• 57365-55-6 hept-6-yne-1,5-diol 
• 87184-80-3 5-tert-butyldimethylsilyloxypentanal 
• 202604-18-0 7-tert-butyldimethylsilyloxy-3-hydroxy-1-trimethylsilylhept-1-yne 
• 110-87-2 3,4-dihydro-2H-pyran 
• 2761-33-3 2-acetoxytetrahydropyran 
• 536-74-3 phenylacetylene 

Downstream Products

• 52426-83-2 2-vinyltetrahydro-2H-pyran 
• 76928-55-7 hepta-5,6-dien-1-al 
• 6671-92-7 8-Oxabicyclo<3.2.1>oct-6-ene 
• 106-99-0 buta-1,3-diene 
• 107-02-8 acrolein 
• 42540-33-0 cyclohex-2-enecarbaldehyde 
• 3857-14-5 2-ethyltetrahydropyran 
• 113297-14-6 1,7-dioxaspiro<5.5>undec-4-ene 
• 1029359-12-3 3-[4-(2-fluorobenzyl)piperazin-1-yl]-6-(tetrahydro-2H-pyran-2-ylethynyl)pyridazine 
• 1098108-63-4 tert-butyl 3-hydroxy-3-(3-((tetrahydro-2H-pyran-2-yl)ethynyl)phenyl) propylcarbamate 

Relevant articles and documents

Diastereoselective, Zinc-Catalyzed Alkynylation of α-Bromo Oxocarbenium Ions

We have developed a bromination/alkynylation sequence that enables efficient transformation of simple cyclic enol ethers to difunctionalized products. The success of this strategy relies on a highly diastereselective, zinc-catalyzed addition of terminal a

A new procedure for highly stereoselective and regioselective synthesis of 2-ethynyl-3-hydroxytetrahydropyran derivatives based on alkyne-Co2(CO)6 complex

Treatment of trans-epoxides 3 with Co2(CO)8 gave the corresponding cobalt complexes, which were subsequently exposed to a catalytic amount of BF3·OEt2 at -78°C to provide exclusively cis-2-ethynyl-3- hydroxytetrahydropyran derivatives via endo mode cyclization pathway. cis- Congeners, cis-3 afforded the corresponding trans tetrahydropyran derivatives exclusively. This novel cyclization has been found to proceed with retention of configuration at the propynyl stereogenic center. Requirement for stereoselectivity in cyclization was discussed.