769944-73-2 Usage
Description
3-(4-Bromophenyl)piperidine-1-carboxylic acid tert-butyl ester, also known as tert-Butyl 3-(4-Bromophenyl)piperidine-1-carboxylate, is an organic compound that serves as a crucial intermediate in the synthesis of pharmaceuticals. It is characterized by its molecular structure, which includes a bromophenyl group attached to a piperidine ring and a tert-butyl ester group. 3-(4-Bromophenyl)piperidine-1-carboxylic acid tert-butyl ester plays a significant role in the development of novel therapeutic agents.
Uses
Used in Pharmaceutical Industry:
3-(4-Bromophenyl)piperidine-1-carboxylic acid tert-butyl ester is used as an intermediate for the synthesis of Niraparib (N481400), a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor. Niraparib is particularly efficacious in treating BRCA-1 and -2 mutant tumors, which are associated with an increased risk of developing certain types of cancer, such as ovarian, breast, and pancreatic cancer.
3-(4-Bromophenyl)piperidine-1-carboxylic acid tert-butyl ester's role as an intermediate in the production of Niraparib highlights its importance in the pharmaceutical industry, as it contributes to the development of targeted therapies for cancer patients with specific genetic mutations. By inhibiting PARP, Niraparib can help prevent the repair of damaged DNA in cancer cells, leading to cell death and potentially improving the prognosis for patients with BRCA-1 and -2 mutations.
Check Digit Verification of cas no
The CAS Registry Mumber 769944-73-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,6,9,9,4 and 4 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 769944-73:
(8*7)+(7*6)+(6*9)+(5*9)+(4*4)+(3*4)+(2*7)+(1*3)=242
242 % 10 = 2
So 769944-73-2 is a valid CAS Registry Number.
769944-73-2Relevant articles and documents
INDOLO HEPTAMYL OXIME ANALOGUE AS PARP INHIBITOR
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, (2021/12/15)
Disclosed is a type of indolo heptamyl oxime compounds as a PARP inhibitor. Specifically disclosed are a compound as represented by formula (II) and a pharmaceutically acceptable salt thereof.
Conversion of Ester Moieties to 4-Bromophenyl Groups via Electrocyclic Reaction of Dibromocyclopropanes
Ueda, Kyosuke,Umihara, Hirotatsu,Yokoshima, Satoshi,Fukuyama, Tohru
, p. 3191 - 3193 (2015/07/15)
(Chemical Equation Presented) Conversion of ester moieties into 4-bromophenyl groups was effected by means of a four-step protocol: a Grignard reaction of the ester with allylmagnesium halides, a ring-closing metathesis, dibromocyclopropanation, and an electrocyclic reaction of the dibromocyclopropanes.
2, 3, 6-TRISUBSTITUTED-4-PYRIMIDONE DERIVATIVES
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Page 289-290, (2008/06/13)
A pyrimidone derivative having tau protein kinase 1 inhibitory activity which is represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof; useful for prventive and/or therapeutic treatment of diseass such as neurodegenerative diseases (e.g. Alzheimer disease); wherein Q represents CH or nitrogen atom; R represents a C1-C12 alkyl group; the ring of Formula (I): represents piperazine ring or piperidine ring; each X independently represents a C1-C8 alkyl group, an optionally partially hydrogenated C6-C10 aryl ring, an indan ring or the like; m represents an integer of 1 to 3; each Y independently represents a halogen atom, a hydroxy group, a cyano group, a C1-C6 alkyl group or the like; n represents an integer of 0 to 8; when X and Y or two Y groups are attached on the same carbon atom, they may combine to each other to form a C2-C6 alkylene group.
