77086-19-2

Basic information

• Product Name: (+)-MK 801 MALEATE
• Synonyms: (+)-MK-801 HYDROGEN MALEATE;(-)-MK 801 MALEATE;(+)-MK 801 MALEATE;(5R,10S)-(+)-5-METHYL-10,11-DIHYDRO-5H-DIBENZO[A,D]CYCLOHEPTEN-5,10-IMINE HYDROGEN MALEATE;(5R,10S)-(-)-5-METHYL-10,11-DIHYDRO-5H-DIBENZO[A,D]CYCLOHEPTEN-5,10-IMINE MALEATE;(5R,10S)-(+)-5-METHYL-10,11-DIHYDRO-5H-DIBENZO[A,D]-CYCLOHEPTEN-5-10-IMINE, MALEATE;DIZOCILPINE MALEATE;(5R,10S)-(-)-5-Methyl-10,11-dihydro-(5H)-dibenzo[a.d]cylcoheptene-5,10-iminemaleate
• CAS NO: 77086-19-2
• Molecular Formula: C₁₆H₁₅N
• Molecular Weight: 337.37
• Product Categories: Glutamate receptor;Glutamate
• Mol File: 77086-19-2.mol
• Article Data: 2

Chemical Properties

• Melting Point: 68.5-69.5°
• Appearance: white/solid
• Storage Temp.: 0-6°C
• Solubility: DMSO: >20mg/mL
• CAS DataBase Reference: (+)-MK 801 MALEATE(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-MK 801 MALEATE(77086-19-2)
• EPA Substance Registry System: (+)-MK 801 MALEATE(77086-19-2)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 77086-19-2(Hazardous Substances Data)

Usage

Uses

Biochemical probe for NMDA receptors.

General Description

(-)-MK-801 hydrogen maleate is a less potent stereoisomer of (+)-MK-801.

Biological Activity

Less active enantiomer (10-fold less potent in behavioral studies) than (+)-MK 801 maleate ((5S,10R)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate ).

Biochem/physiol Actions

Less active enantiomer of (+)-MK-801 hydrogen maleate

Upstream product

• 124070-25-3 C₂₁H₂₄N₂ 
• 50537-17-2 (+/-)-des-methyl MK-801 
• 124070-07-1 C₂₀H₂₂N₂ 
• 1210-35-1 10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-one 
• 2732-90-3 5-methylene-10,11-dihydro-5H-dibenzo[a,d]cycloheptene 
• 24167-43-9 5-methyl-10,11-dihydro-5H-dibenzo[a,d][7]annulene 

Downstream Products

• 125134-28-3 (5S,10R)-(+)-3-bromo-10,11-dihydro-5-methyl-5H-dibenzocyclohepten-5,10-imine 

Relevant articles and documents

Intermolecular Radical C(sp3)?H Amination under Iodine Catalysis

The direct amination of aliphatic C?H bonds has remained one of the most tantalizing transformations in organic chemistry. Herein, we report on a unique catalyst system, which enables the elusive intermolecular C(sp3)?H amination. This practical synthetic strategy provides access to aminated building blocks and fosters innovative multiple C?H amination within a new approach to aminated heterocycles. The synthetic utility is demonstrated by the synthesis of four relevant pharmaceuticals.