77107-46-1

Basic information

• Product Name: CALMODULIN
• Synonyms: PHOSPHODIESTERASE 3':5'-CYCLIC NUCLEOTIDE ACTIVATOR (HUMAN);PHOSPHODIESTERASE 3,5'-CYCLIC-NUCLEOTIDE ACTIVATOR;PHOSPHODIESTERASE 3':5'-CYCLIC NUCLEOTIDE-ACTIVATOR;PHOSPHODIESTERASE 3'5'-CYCLIC NUCLEOTIDE-ACTIVATOR;PHOSPHODIESTERASE 3':5'-CYCLIC NUCLEOTIDE ACTIVATOR BOVINE;CA2+/CALMODULIN, BOVINE;CA2+/CALMODULIN, HUMAN;CALMODULIN
• CAS NO: 77107-46-1
• Molecular Weight: 0
• EINECS: 277-370-7
• Product Categories: proteins
• Mol File: 77107-46-1.mol
• Article Data: 0

Chemical Properties

• Appearance: /lyophilized powder
• Storage Temp.: −20°C
• Water Solubility: Soluble in water at 1mg/ml
• CAS DataBase Reference: CALMODULIN(CAS DataBase Reference)
• NIST Chemistry Reference: CALMODULIN(77107-46-1)
• EPA Substance Registry System: CALMODULIN(77107-46-1)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 77107-46-1(Hazardous Substances Data)

Usage

Description

Calmodulin, also known as CaM, is a small, highly conserved calcium-binding protein found in eukaryotic cells. It plays a crucial role in regulating various cellular processes by binding to target proteins in response to changes in intracellular calcium levels. Calmodulin possesses four EF-hand calcium-binding domains, which allow it to undergo conformational changes upon calcium binding, enabling it to interact with a wide range of target proteins.

Uses

Used in Cellular Signaling:
Calmodulin is used as a calcium sensor and signal transducer for various cellular processes. It modulates the activity of target proteins by binding to them in a calcium-dependent manner, thereby regulating processes such as cell growth, differentiation, and apoptosis.
Used in Enzyme Regulation:
Calmodulin is used as a protein activator for the Ca2+-dependent activation of phosphodiesterase, 3′:5′-cyclic nucleotide, P0520. It activates cyclic phosphodiesterase, which is involved in the breakdown of cyclic nucleotides, playing a key role in the regulation of intracellular signaling pathways.
Used in Neuronal Function:
Calmodulin is used in the nervous system to regulate neuronal function. It is involved in the modulation of ion channels, neurotransmitter release, and synaptic plasticity, which are essential for proper neuronal communication and information processing.
Used in Muscle Contraction:
Calmodulin is used in muscle contraction as a regulatory component of the myosin light chain kinase (MLCK). It activates MLCK in a calcium-dependent manner, leading to the phosphorylation of myosin light chains and ultimately resulting in muscle contraction.
Used in Cell Motility:
Calmodulin is used in cell motility as a regulator of actin cytoskeleton dynamics. It interacts with various actin-binding proteins, modulating their activity and promoting the assembly and disassembly of actin filaments, which is crucial for cell movement and migration.
Used in Apoptosis:
Calmodulin is used in the regulation of apoptosis, or programmed cell death. It interacts with pro-apoptotic and anti-apoptotic proteins, modulating their activity and influencing the decision between cell survival and death in response to various stimuli.

Biochem/physiol Actions

Ca2+ binding protein that is required for activation of cyclic nucleotide-dependent phosphodiesterase. It is also a cofactor/activator of nitric oxide synthase, calcineurin, and many kinases including ATPase, myosin light chain kinase, and CAM kinase I, II, and III. It mediates ryanodine receptor activation by cyclic ADP ribose and is involved in intracellular Ca2+ homeostasis.