77123-55-8

Basic information

• Product Name: 3-(TRIMETHYLSILYL)ETHYNYLBENZALDEHYDE
• Synonyms: 3-(TRIMETHYLSILYL)ETHYNYLBENZALDEHYDE;3-[2-(trimethylsilyl)ethynyl]benzaldehyde
• CAS NO: 77123-55-8
• Molecular Formula: C₁₂H₁₄OSi
• Molecular Weight: 202.32
• Mol File: 77123-55-8.mol
• Article Data: 26

Chemical Properties

• Boiling Point: 265.6 °C at 760 mmHg
• Flash Point: >110℃
• Appearance: /
• Density: 0.962 g/mL at 25 °C
• Vapor Pressure: 7.24E-11mmHg at 25°C
• Refractive Index: n20/D1.547
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-(TRIMETHYLSILYL)ETHYNYLBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(TRIMETHYLSILYL)ETHYNYLBENZALDEHYDE(77123-55-8)
• EPA Substance Registry System: 3-(TRIMETHYLSILYL)ETHYNYLBENZALDEHYDE(77123-55-8)

Safety Data

• Hazard Codes: F,T,Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 77123-55-8(Hazardous Substances Data)

Usage

General Description

3-(Trimethylsilyl)ethynylbenzaldehyde is a chemical compound with the molecular formula C12H14OSi. It is a derivative of benzaldehyde and contains a trimethylsilyl group and an ethynyl functional group. 3-(TRIMETHYLSILYL)ETHYNYLBENZALDEHYDE is commonly used in organic synthesis as a reagent in various reactions. It is often used in the preparation of heterocyclic compounds, particularly in the synthesis of pharmaceuticals and agrochemicals. Additionally, the trimethylsilyl group can be easily removed under mild conditions, making this compound useful in the protection and deprotection of functional groups in organic synthesis. Overall, 3-(trimethylsilyl)ethynylbenzaldehyde has a wide range of applications in organic chemistry and is a valuable building block in the synthesis of complex organic molecules.

InChI:InChI=1/C16H17ClN2O3S2/c17-15-14(11-20)23-16(19(15)12-7-3-1-4-8-12)18-24(21,22)13-9-5-2-6-10-13/h2,5-6,9-12H,1,3-4,7-8H2

Upstream product

• 3132-99-8 m-bromobenzoic aldehyde 
• 1066-54-2 trimethylsilylacetylene 
• 696-41-3 m-iodobenzaldehyde 
• 3375-31-3 palladium diacetate 
• 3989-13-7 2-(3-bromophenyl)ethynyltrimethylsilane 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 77123-56-9 3-ethynylbenzaldehyde 
• 530135-81-0 1,4-bis(3-formylphenylethynyl)-2,5-dihexyloxybenzene 
• 530135-84-3 1,4-bis(3-formylphenylethynyl)-2,5-didodecyloxybenzene 

Relevant articles and documents

RET INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

Provided herein are a RET inhibitor, a pharmaceutical composition thereof and uses thereof. In particular, provided is a compound having Formula (I) or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof. Provided is a pharmaceutical composition comprising the compound, and uses of the compound and pharmaceutical composition thereof for the preparation of a medicament, in particular for treatment and prevention of RET-related diseases and conditions, including cancer, irritable bowel syndrome, and/or pain associated with irritable bowel syndrome.

Organocatalysis by a multidentate halogen-bond donor: An alternative to hydrogen-bond based catalysis

A charge neutral iodoethynyl-based multidentate halogen-bond donor was synthesized and successfully utilized as an organocatalyst in a benchmark Ritter-type solvolysis reaction. The catalytic activity was monitored using 1H NMR spectroscopy and

GPR40 agonist and its application

The invention provides a novel benzyne compound and its stereisomer, salt, hydrate or crystal for adjusting G protein coupled receptor 40 (GPR40) functions and especially for preventing or treating diabetes. The invention also provides a useful intermedia