77220-86-1

Basic information

• Product Name: 4-hydroxy-3-methyl-butanoic acid
• Synonyms: 4-hydroxy-3-methyl-butanoic acid;4-Hydroxyisovaleric acid
• CAS NO: 77220-86-1
• Molecular Formula: C₅H₁₀O₃
• Molecular Weight: 118.06
• Mol File: 77220-86-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 277.272 °C at 760 mmHg
• Flash Point: 135.733 °C
• Appearance: /
• Density: 1.14 g/cm³
• Vapor Pressure: 0.000564mmHg at 25°C
• Refractive Index: 1.458
• CAS DataBase Reference: 4-hydroxy-3-methyl-butanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-hydroxy-3-methyl-butanoic acid(77220-86-1)
• EPA Substance Registry System: 4-hydroxy-3-methyl-butanoic acid(77220-86-1)

Safety Data

• Hazardous Substances Data: 77220-86-1(Hazardous Substances Data)

Usage

Description

4-hydroxy-3-methyl-butanoic acid, also known as β-hydroxy-β-methylbutyric acid (HMB), is a naturally occurring compound that is produced in the body during the metabolism of the essential amino acid leucine. It is a promising supplement for muscle health and performance due to its potential benefits in reducing muscle protein breakdown, promoting muscle protein synthesis, and improving muscle recovery after intense exercise.

Uses

Used in Sports Nutrition:
4-hydroxy-3-methyl-butanoic acid is used as a dietary supplement for athletes and individuals seeking to improve their physical performance. It helps in reducing muscle protein breakdown, promoting muscle protein synthesis, and improving muscle recovery after intense exercise, thereby enhancing athletic performance.
Used in Elderly Care:
4-hydroxy-3-methyl-butanoic acid is used as a supplement for elderly individuals to help preserve muscle mass and strength. It may have potential benefits in maintaining muscle health and preventing muscle loss associated with aging.

InChI:InChI=1/C5H10O3/c1-4(3-6)2-5(7)8/h4,6H,2-3H2,1H3,(H,7,8)

Upstream product

• 44647-19-0 (E)-4-hydroxy-3-methylbut-2-enoic acid 
• 71424-95-8 (-)-4-Amino-3-methyl-buttersaeure 
• 1578-14-9 2-bromo-3-methyl-crotonic acid 
• 80573-34-8 α,β-dibromo-β,β-dimethylpropionic acid 
• 97-65-4 2-methylenesuccinic acid 
• 188692-77-5 (3S)-4-<(1-ethoxyethyl)oxy>-3-methylbutanenitrile 

Downstream Products

• 66261-30-1 (S)-4-(benzyloxy)-2-methylbutan-1-ol 
• 66261-34-5 (2S,6R)-8-(benzyloxy)-2,6-dimethyloctanol 
• 156592-96-0 (2S,6S)-8-(benzyloxy)-1-<(tert-butyldimethylsilyl)oxy>-2,6-dimethyloctane 
• 156592-97-1 (2S,6R)-8-(benzyloxy)-1-(phenylsulfonyl)-2,6-dimethyloctane 
• 188692-79-7 (2S,6S)-8-(benzyloxy)-1-<(tert-butyldimethylsilyl)oxy>-2,6-dimethyl-5-(phenylsulfonyl)octane 
• 188692-83-3 (2S,6R,10S,14R)-16-(benzyloxy)-1-<(tert-butyldimethylsilyl)oxy>-2,6,10,14-tetramethyl-8-(phenylsulfonyl)hexadecane 
• 156593-02-1 1-O-benzyl-2,3-bis-O-<(3R,7R,11S,15S)-16-hydroxy-3,7,11,15-tetramethylhexadecanyl>-sn-glycerol 
• 156593-03-2 (2S,6S,10R,14R)-16-[(S)-2-Benzyloxy-1-((3R,7R,11S,15S)-3,7,11,15-tetramethyl-16-oxo-hexadecyloxymethyl)-ethoxy]-2,6,10,14-tetramethyl-hexadecanal 
• 156593-01-0 1-O-benzyl-2,3-bis-O-<(3R,7R,11S,15S)-16-<(tert-butyldimethylsilyl)oxy>-3,7,11,15-tetramethylhexadecanyl>-sn-glycerol 
• 88408-99-5 (2S)-4-(benzyloxy)-1-(phenylsulfonyl)-2-methylbutane 

Relevant articles and documents

Aqueous-phase hydrogenation of biomass-derived itaconic acid to methyl-γ-butyrolactone over Pd/C catalysts: Effect of pretreatments of active carbon

The effect of active carbon pretreatment on the catalytic performance of Pd/C catalysts in the hydrogenation of itaconic acid was studied. The catalysts were prepared by deposition-precipitation and characterized by XRD, BET, NH3-TPD, TEM and F

The First Synthesis of an Archaebacterial 36-Membered Macrocyclic Diether Lipid

The archaebacterial macrocyclic diether lipid featuring of 36-membered ring is synthesized by the McMurry coupling as a key step.