77227-81-7

Basic information

• Product Name: 3,5-Dichloro-4-fluorobenzotrifluoride
• Synonyms: 1,3-DICHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)BENZENE;3,5-DICHLORO-ALPHA,ALPHA,ALPHA-4-TETRAFLUOROTOLUENE;3,5-dichloro-4-fluoro-alpha,alpha,alpha-trifluorotoluene;3,5-DICHLORO-4-FLUOROBENZOTRIFLUORIDE;Benzene, 1,3-dichloro-2-fluoro-5-(trifluoromethyl)-;3,5-Dichloro-4-fluorobenzotrifluoride 98%;3,5-Dichloro-4-fluorobenzotrifluoride98%;3,5-Dichloro-4-fluoronitrobezene
• CAS NO: 77227-81-7
• Molecular Formula: C₇H₂Cl₂F₄
• Molecular Weight: 232.99
• EINECS: -0
• Product Categories: Aryl;C7;Halogenated Hydrocarbons;Aryl Fluorinated Building Blocks;Building Blocks;Chemical Synthesis;Fluorinated Building Blocks;Halogenated Hydrocarbons;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks
• Mol File: 77227-81-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 166-168 °C(lit.)
• Flash Point: 164 °F
• Appearance: clear light yellow liquid
• Density: 1.555 g/mL at 25 °C(lit.)
• Vapor Pressure: 1.54mmHg at 25°C
• Refractive Index: n20/D 1.462(lit.)
• BRN: 6199573
• CAS DataBase Reference: 3,5-Dichloro-4-fluorobenzotrifluoride(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Dichloro-4-fluorobenzotrifluoride(77227-81-7)
• EPA Substance Registry System: 3,5-Dichloro-4-fluorobenzotrifluoride(77227-81-7)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-41
• Safety Statements: 26-36
• RIDADR: UN 2810 6.1/PG 3
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 77227-81-7(Hazardous Substances Data)

Usage

Description

3,5-Dichloro-4-fluorobenzotrifluoride is an organic compound characterized by its molecular structure that features two chlorine atoms at the 3rd and 5th positions, a fluorine atom at the 4th position, and three fluorine atoms attached to a benzene ring. 3,5-Dichloro-4-fluorobenzotrifluoride is known for its potential reactivity and utility in chemical synthesis processes.

Uses

Used in Pharmaceutical Industry:
3,5-Dichloro-4-fluorobenzotrifluoride is used as a synthetic intermediate for the development of pharmaceutical compounds. Its unique structure allows it to be a key component in the synthesis of complex organic molecules, particularly those with potential therapeutic applications.
Used in Chemical Research:
In the field of chemical research, 3,5-Dichloro-4-fluorobenzotrifluoride serves as a valuable precursor for the synthesis of various organic compounds. Its reactivity and structural features make it suitable for use in the development of new chemical entities and the exploration of novel chemical reactions.
Used in the Synthesis of 3-[4-[1-(2,6-dichloro-3-iodo-4-trifluoromethylphenyl)-5-iodopyrazolo]]-3-(trifluoromethyl)diazirine:
3,5-Dichloro-4-fluorobenzotrifluoride is specifically used as a starting material in the synthesis of the complex molecule 3-[4-[1-(2,6-dichloro-3-iodo-4-trifluoromethylphenyl)-5-iodopyrazolo]]-3-(trifluoromethyl)diazirine. This application highlights its importance in the creation of specialized chemical compounds with potential applications in various industries.

InChI:InChI=1/C7H2Cl2F4/c8-4-2-6(10)5(9)1-3(4)7(11,12)13/h1-2H

Upstream product

• 50594-82-6 1-trifluoromethyl-3,4,5-trichlorobenzene 
• 13755-29-8 sodium tetrafluoroborate 
• 24279-39-8 2,6-dichloro-4-(trifluoromethyl)aniline 

Downstream Products

• 98191-30-1 3,5-dichloro-4-fluorobenzoic acid 
• 452098-03-2 3-(2,6-dichloro-4-trifluoromethylphenyloxy)-5-methylpyrazole 
• 452098-98-5 N-allyl-3-(2,6-dichloro-4-trifluoromethylphenyloxy)-5-methylpyrazole-1-carboxamide 
• 249893-20-7 3-Amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-1,2,4-triazole 
• 129931-45-9 3-chloro-2-fluoro-5-(trifluoromethyl)benzoic acid 
• 133306-97-5 1-(2,6-dichloro-4-trifluoromethylphenyl)-5-amino-4-trifluoromethylpyrimidin-6-one 
• 115551-51-4 4-ethoxy carbonyl-1-(2,6-dichloro-4-trifluoromethyl-phenyl)-2-pyridone 

Relevant articles and documents

PROCESS FOR PREPARING 2,6-DICHLORO-4-(TRIFLUOROMETHYL)PHENYLHYDRAZINE USING MIXTURES OF DICHLORO-FLUORO-TRIFLUOROMETHYLBENZENES

This invention relates to a process for preparing 2,6-dichloro-4- (trifluoromethyl)phenylhydrazine of the formula (I) wherein a mixture comprising 1,3-dichloro-2-fluoro-5-trifluoromethylbenzene and 1,2-dichloro-3-fluoro-5-trifluoromethylbenzene is reacted with a hydrazine source selected from hydrazine, hydrazine hydrate or acid addition salts of hydrazine, optionally in the presence of at least one organic solvent.

Substituted diphenyl ethers

A compound of the formula: STR1 and salts and esters thereof, useful as intermediates for the preparation of compounds of the formula STR2 wherein R1 is an alkyl group optionally substituted by one or more fluorine atoms or by an optionally substituted phenyl group R2 is No2 or Cl and R6 is a hydrogen atom or an alkyl group of 1 to 4 carbon atoms.