77232-38-3

Basic information

• Product Name: 4-(PYRIMIDIN-2-YL)BENZALDEHYDE
• Synonyms: AKOS BAR-2385;4-(PYRIMIDIN-2-YL)BENZALDEHYDE;2-(4-Formylphenyl)pyrimidine;2-(4-Formylphenyl)pyrimidine, 2-(4-Formylphenyl)-1,3-diazine
• CAS NO: 77232-38-3
• Molecular Formula: C₁₁H₈N₂O
• Molecular Weight: 184.19
• EINECS: 604-604-1
• Product Categories: Phenyls & Phenyl-Het;Aldehydes;Phenyls & Phenyl-Het
• Mol File: 77232-38-3.mol
• Article Data: 9

Chemical Properties

• Melting Point: 111.5-112.0 °C
• Boiling Point: 257.101 °C at 760 mmHg
• Flash Point: 113.036 °C
• Appearance: /
• Density: 1.205 g/cm³
• Vapor Pressure: 0.015mmHg at 25°C
• Refractive Index: 1.621
• Storage Temp.: 2-8°C
• PKA: 0.46±0.13(Predicted)
• CAS DataBase Reference: 4-(PYRIMIDIN-2-YL)BENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(PYRIMIDIN-2-YL)BENZALDEHYDE(77232-38-3)
• EPA Substance Registry System: 4-(PYRIMIDIN-2-YL)BENZALDEHYDE(77232-38-3)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-36-43
• Safety Statements: 26-36/37
• Hazardous Substances Data: 77232-38-3(Hazardous Substances Data)

Usage

General Description

4-(Pyrimidin-2-yl)benzaldehyde is a chemical compound with the molecular formula C12H8N2O. It is a yellow crystalline solid that is commonly used as an intermediate in the synthesis of various pharmaceuticals and organic compounds. 4-(PYRIMIDIN-2-YL)BENZALDEHYDE belongs to the class of pyrimidine compounds, which are widely used in the pharmaceutical industry for their diverse pharmacological properties. 4-(Pyrimidin-2-yl)benzaldehyde is often used in the production of anti-cancer drugs, anti-inflammatory agents, and other therapeutic compounds. It is also used as a reagent and building block in organic synthesis, making it an important chemical in the field of medicinal and pharmaceutical chemistry.

InChI:InChI=1/C11H8N2O/c14-8-9-2-4-10(5-3-9)11-12-6-1-7-13-11/h1-8H

Upstream product

• 77232-37-2 2-(4-Bromomethyl-phenyl)-pyrimidine 
• 87199-17-5 4-formylphenylboronic acid, 
• 6326-27-8 p-methylbenzamidine hydrochloride 
• 21139-61-7 2-(4-methylphenyl)-4,6-dichloropyrimidine 
• 77232-12-3 2-(4-methylphenyl)-4,6-dihydroxypyrimidine 
• 77232-13-4 2-p-tolyl-pyrimidine 
• 4595-60-2 2-bromopyrimidine 

Downstream Products

• 77232-07-6 (4-Chloro-phenyl)-[1-(4-pyrimidin-2-yl-phenyl)-meth-(E)-ylidene]-amine 
• 199678-12-1 4-(pyrimidine-2-yl)benzoic acid 
• 344586-21-6 2-{4-[(E)-2-(4-Pyrimidin-2-yl-phenyl)-vinyl]-phenyl}-benzooxazole 
• 503176-25-8 (2E)-3-[4-(2-pyrimidinyl)phenyl]-2-propenal 
• 545424-74-6 (2Z)-2-Fluoro-3-[4-(2-pyrimidinyl)phenyl]-2-propenoic Acid Ethyl Ester 
• 1206604-17-2 C₅₀H₆₀N₄O₁₂ 
• 1394898-78-2 C₂₃H₃₀N₄O₂ 
• 1383719-99-0 C₂₆H₂₈N₆OS 

Relevant articles and documents

BROAD SPECTRUM ANTIVIRAL COMPOSITIONS AND METHODS

Novel thiazole- and isoquinoline- containing compounds are presented that are useful for treating and/or preventing broad-spectrum viral infections. Methods of treating and/or preventing broad-specturm viral infections are also presented. These compounds have shown inhibitio of HCMV, influenza viruses, Zika virus, BK Virus and RSV replication in cell-based assays.

Methods of treatment using an EP2 selective receptor agonist

The present invention relates to methods of treating pulmonary hypertension, facilitating joint fusion, facilitating tendon and ligament repair, reducing the occurrence of secondary fracture, treating avascular necrosis, facilitating cartilage repair, facilitating bone healing after limb transplantation, facilitating liver regeneration, facilitating wound healing, reducing the occurrence of gastric ulceration, treating hypertension, facilitating the growth of tooth enamel or finger or toe nails, treating glaucoma, treating ocular hypertension, and repairing damage caused by metastatic bone disease using an EP2 selective receptor agonist.

THIENOPYRIMIDINEDIONES AND THEIR USE IN THE MODULATION OF AUTOIMMUNE DISEASE

The invention relates to thienopyrimidinediones of formula (1) wherein R1 and R2 each independently represent a C1-6akyl, C3-6alkyl, C3-6alkenyl, C3-5cycloalkylC1-3alkyl or Csub