77308-57-7

Basic information

• Product Name: 2-(9H-fluoren-2-ylcarbonyl)benzoic acid
• CAS NO: 77308-57-7
• Molecular Formula: C₂₁H₁₄O₃
• Molecular Weight: 314.3341
• Mol File: 77308-57-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 586.6°C at 760 mmHg
• Flash Point: 322.6°C
• Density: 1.315g/cm³
• Vapor Pressure: 1.33E-14mmHg at 25°C
• Refractive Index: 1.682
• CAS DataBase Reference: 2-(9H-fluoren-2-ylcarbonyl)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(9H-fluoren-2-ylcarbonyl)benzoic acid(77308-57-7)
• EPA Substance Registry System: 2-(9H-fluoren-2-ylcarbonyl)benzoic acid(77308-57-7)

Safety Data

• Hazardous Substances Data: 77308-57-7(Hazardous Substances Data)

Usage

Physical form

White crystalline solid

Solubility

Soluble in organic solvents

Uses

+ Precursor for the synthesis of pharmaceuticals, agrochemicals, and dyes
+ Building block for the creation of new chemical compounds in research laboratories

Structural and chemical properties

Presence of the fluoren-2-ylcarbonyl group

Upstream product

• 85-44-9 phthalic anhydride 
• 86-73-7 9H-fluorene 

Downstream Products

• 72834-06-1 2-(fluorene-2-carbonyl)-benzoic acid methyl ester 
• 72834-21-0 (o-carboxybenzyl)-2 fluorene 
• 86-73-7 9H-fluorene 
• 98257-42-2 2-(benzyl)-9H-fluorene 
• 72834-10-7 2-(9-oxo-fluorene-2-carbonyl)-benzoic acid 
• 77308-66-8 2-(9H-Fluoren-2-ylmethyl)-phenylamine 
• 77308-64-6 2-(2-Isocyanato-benzyl)-9H-fluorene 
• 77308-62-4 2-(9H-Fluoren-2-ylmethyl)-benzoyl chloride 
• 77308-63-5 2-(9H-Fluoren-2-ylmethyl)-benzoyl azide 
• 77308-59-9 di(o-carboxybenzyl)-2,7 fluorene 
• 77308-58-8 C₂₉H₂₀O₅ 

Relevant articles and documents

Sensitizing compound, photosensitive resin composition, and applications thereof

The invention provides a sensitizing compound, a photosensitive resin composition and applications of the sensitizing compound and the photosensitive resin composition. The sensitizing compound has astructure as shown in a general formula (I), wherein R1a, R2a, R3a, R4a, R1b, R2b, R1c, R2c, R3c and R4c each independently represent hydrogen, linear or branched alkyl, cycloalkyl, cycloalkyl alkyl,alkyl cycloalkyl, -NO2, -ORA, -CORA, -COORA, -SRA, -SO2RA or -CONRARB; in the general formula (I), A represents a group shown as the specification, *O*, *S*, a group shown as the specification or a group shown as the specification; or A in the general formula (I) represents -CR1R2. Compared with the common sensitizer at present, the compound with the general formula (I) has a large molecular weight and stable structure, so that the compound has the characteristics of high sensitization, difficulty in sublimation, low migration, easy preparation and low cost.

Synthesis and Biological Evaluation of New Phthalazinone Derivatives as Anti-Inflammatory and Anti-Proliferative Agents

The chemistry of phthalazine derivatives has been of increasing interest since many of these compounds have found many chemotherapeutic applications. So this study aims to synthesize a library of phthalazine derivatives and to investigate their anti-inflammatory and anti-proliferative activities. Sixteen new phthalazinone derivatives (2a-p) were synthesized and tested for their in vitro antiproliferative and in vivo anti-inflammatory activities. All the synthesized compounds were identified and characterized by IR, 1H NMR, 13C NMR spectroscopy, and MS. Two compounds, 2b and 2i, showed significant anti-inflammatory activity comparable with that of the standard drug etoricoxib in the carrageenan-induced rat paw edema model at 3 and 5 h, respectively. Three compounds (2h, 2j, and 2g) showed moderate sensitivity toward the renal cancer cell line UO-31. A library of new phthalazone compounds (2a-p) was synthesized as dual inhibitors (COX-2/LOX-5) and evaluated for their anti-inflammatory, anticancer activities. Two compounds showed significant anti-inflammatory activity comparable with that of the standard drug etoricoxib, whereas three compounds showed moderate sensitivity toward the renal cancer cell line UO-31.