77420-65-6

Basic information

• Product Name: 2,2-Dimethyl-propionic acid [1-(4-nitro-phenyl)-meth-(E)-ylidene]-hydrazide
• Synonyms: 2,2-Dimethyl-propionic acid [1-(4-nitro-phenyl)-meth-(E)-ylidene]-hydrazide
• CAS NO: 77420-65-6
• Molecular Weight: 249.269
• Mol File: 77420-65-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2,2-Dimethyl-propionic acid [1-(4-nitro-phenyl)-meth-(E)-ylidene]-hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-Dimethyl-propionic acid [1-(4-nitro-phenyl)-meth-(E)-ylidene]-hydrazide(77420-65-6)
• EPA Substance Registry System: 2,2-Dimethyl-propionic acid [1-(4-nitro-phenyl)-meth-(E)-ylidene]-hydrazide(77420-65-6)

Safety Data

• Hazardous Substances Data: 77420-65-6(Hazardous Substances Data)

Upstream product

• 42826-42-6 pivalohydrazide 
• 555-16-8 4-nitrobenzaldehdye 
• 75-98-9 Trimethylacetic acid 

Downstream Products

• 77420-58-7 1-chloro-1-(1,1-dimethylethyl)-4-(4-nitrophenyl)-2,3-diazabutadiene 

Relevant articles and documents

Indoline Catalyzed Acylhydrazone/Oxime Condensation under Neutral Aqueous Conditions

Acylhydrazones formation has been widely applied in materials science and biolabeling. However, their sluggish condensation rate under neutral conditions limits its application. Herein, indolines with electron-donating groups are reported as a new catalyst scaffold, which can catalyze acylhydrazone, hydrazone, and oxime formation via an iminium ion intermediate. This new type of catalyst showed up to 15-fold rate enhancement over the traditional anilinecatalyzed reaction at neutral conditions. The identified indoline catalyst was successfully applied in hydrogel formation.