77427-00-0

Basic information

• Product Name: L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-L-tyrosylglycylglycyl-L-phenylalanyl-, 1,1-dimethylethyl ester
• Synonyms: Boc-Tyr-Gly-Gly-Phe-Leu-O-t-butyl;Boc-Tyr-Gly-Gly-Phe-Leu-OC4H9-t
• CAS NO: 77427-00-0
• Molecular Formula: C37H53N5O9
• Molecular Weight: 711.856
• Mol File: 77427-00-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 981.4±65.0 °C(Predicted)
• Density: 1.182±0.06 g/cm3(Predicted)
• CAS DataBase Reference: L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-L-tyrosylglycylglycyl-L-phenylalanyl-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-L-tyrosylglycylglycyl-L-phenylalanyl-, 1,1-dimethylethyl ester(77427-00-0)
• EPA Substance Registry System: L-Leucine, N-[(1,1-dimethylethoxy)carbonyl]-L-tyrosylglycylglycyl-L-phenylalanyl-, 1,1-dimethylethyl ester(77427-00-0)

Safety Data

• Hazardous Substances Data: 77427-00-0(Hazardous Substances Data)

Upstream product

• 82362-18-3 Z-Gly-Phe-Leu-OBu^t 
• 75893-08-2 Boc-Tyr-Gly-NHNH₂ 
• 28635-78-1 L-phenylalanyl-L-leucine tert-butyl ester 
• 7733-20-2 Boc-L-Tyr-Gly-OMe 
• 3978-80-1 Boc-Tyr-OH 
• 82362-19-4 Gly-Phe-Leu(t-Bu) 
• 75903-26-3 Boc-Tyr-Gly-N₃ 
• 77426-99-4 AcOH-Gly-Gly-Phe-Leu-O-t-butyl 

Downstream Products

• 58822-25-6 Leu-enkephalin 

Relevant articles and documents

Ammonium formate catalytic transfer hydrogenation: A convenient method for removal of halogenated benzyloxycarbonyl and benzyl protecting groups in peptide synthesis

A new application of ammonium formate catalytic transfer hydrogenolysis, in the presence of palladised carbon, for removal of 2-chlorobenzyloxycarbonyl (2-ClZ), 2,6-dichlorobenzyl (2,6-Cl2Bzl), bromobenzyloxycarbonyl (BrZ) and phenacyl ester (OPa) from amino acids, peptides and high molecular weight polymers is reported.

An advantageous method for the rapid removal of hydrogenolysable protecting groups under ambient conditions; synthesis of leucine-enkephalin

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