77450-05-6 Usage
General Description
(+)-PPM is a synthetic chemical that belongs to the class of phenylpyrrolidine derivatives. It is a potent and selective dopamine reuptake inhibitor, meaning it inhibits the reuptake of dopamine in the brain, leading to increased dopamine levels and enhanced dopaminergic neurotransmission. This chemical has been studied for its potential use in the treatment of neurodegenerative disorders such as Parkinson's disease and attention deficit hyperactivity disorder (ADHD). Studies have shown that (+)-PPM has high affinity and selectivity for the dopamine transporter, making it an attractive candidate for further research and potential therapeutic development.
Check Digit Verification of cas no
The CAS Registry Mumber 77450-05-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,7,4,5 and 0 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 77450-05:
(7*7)+(6*7)+(5*4)+(4*5)+(3*0)+(2*0)+(1*5)=136
136 % 10 = 6
So 77450-05-6 is a valid CAS Registry Number.
77450-05-6Relevant articles and documents
Asymmetric hydrogenation of 2-benzylidenesuccinic acid 4-[(4-BOC-amino)-1-piperidide] monoamide: Key step in a process for large scale preparation of a renin inhibitor
Jendralla
, p. 494 - 498 (2007/10/02)
The N-terminal component 4 of an orally active renin inhibitor is prepared on kg-scale by asymmetric hydrogenation of the title compound 3. Enantioselectivities of several homogeneous homochiral rhodium(I)- and ruthenium(II)-diphosphine catalysts are compared.
