77469-44-4

Basic information

• Product Name: 1-(2-chloroethyl)-3-[2-[2-[(2-chloroethyl-nitroso-carbamoyl)amino]ethy ldisulfanyl]ethyl]-1-nitroso-urea
• Synonyms: 1-(2-chloroethyl)-3-[2-[2-[(2-chloroethyl-nitroso-carbamoyl)amino]ethy ldisulfanyl]ethyl]-1-nitroso-urea;N,N'-bis((2-chloroethyl)nitrosocarbamoyl)cystamine
• CAS NO: 77469-44-4
• Molecular Formula: C10H18Cl2N6O4S2
• Molecular Weight: 421.36
• Mol File: 77469-44-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.7040 (rough estimate)
• Refractive Index: 1.6000 (estimate)
• CAS DataBase Reference: 1-(2-chloroethyl)-3-[2-[2-[(2-chloroethyl-nitroso-carbamoyl)amino]ethy ldisulfanyl]ethyl]-1-nitroso-urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-chloroethyl)-3-[2-[2-[(2-chloroethyl-nitroso-carbamoyl)amino]ethy ldisulfanyl]ethyl]-1-nitroso-urea(77469-44-4)
• EPA Substance Registry System: 1-(2-chloroethyl)-3-[2-[2-[(2-chloroethyl-nitroso-carbamoyl)amino]ethy ldisulfanyl]ethyl]-1-nitroso-urea(77469-44-4)

Safety Data

• Safety Statements: −, SOx and NOx." target="_blank">Poison by ingestion and intraperitoneal routes. Mutation data reported. When heated to de
• Hazardous Substances Data: 77469-44-4(Hazardous Substances Data)

Usage

Safety Profile

Poison by ingestion andintraperitoneal routes. Mutation data reported. Whenheated to decomposition it emits toxic fumes of Cl-, SOxand NOx.

Upstream product

• 80354-51-4 N-(chloro-2 ethyl)N-nitrosocarbamate de trichloro-2,4,5 phenyle 
• 56-17-7 cystamine dihydrochioride 
• 80354-53-6 N-(2-chloroethyl)-N-nitrosocarbamic acid pentachlorophenyl ester 
• 80354-49-0 N-(2-chloroethyl)-N-nitrosocarbamic acid N-hydroxypyrrolidine-2,5-dione ester 
• 80354-55-8 pentafluorophenyl N-(2-chloroethyl)-N-nitrosocarbamate 
• 77456-13-4 bis N,N'-(N-chloro-2 ethylcarbamoyl)cystamine 
• 90213-05-1 S-trityl N- cysteamine 

Relevant articles and documents

New oncostatic nitrosourea of clinical interest. II. Study of CNCC constituents

CNCC is an isomeric mixture of dinitrosated chloroethyl nitrosoureas. Two of these being identified, a complete analysis of the isolated mixture obtained through nitrosation of the urea corresponding to cystamine is then possible. Furthermore, a new synth

Activated N-Nitrosocarbamates for Regioselective Synthesis of N-Nitrosoureas

A practical and convenient method for synthesizing antitumor compounds, N-alkyl-N-nitrosoureas, regioselectively nitrosated on the nitrogen atom bearing the alkyl group is proposed.N-Alkyl-N-nitrosocarbamates are interesting intermediates in these syntheses and yield, by reaction with amino compounds, the regioselectively nitrosated N-alkyl-N-nitrosoureas.As an interesting example, N,N'-biscystamine, a new attractive oncostatic derivative, has been prepared.The cytotoxic activity of these various compounds were tested on L1210 leukemia.