7748-59-6Relevant articles and documents
HETEROCYCLIC LSF INHIBITORS AND THEIR USES
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Paragraph 00241-00242, (2021/07/31)
The present invention is directed to heterocyclic SV40 Factor (LSF) inhibitors and their uses. In some implementations, the present invention discloses small-molecule compounds of Formula (I). In some implementations, the compounds of Formula (I) are used
Robust Photocatalytic Method Using Ethylene-Bridged Flavinium Salts for the Aerobic Oxidation of Unactivated Benzylic Substrates
Pokluda, Adam,Anwar, Zubair,Boguschová, Veronika,Anusiewicz, Iwona,Skurski, Piotr,Sikorski, Marek,Cibulka, Radek
supporting information, p. 4371 - 4379 (2021/04/02)
7,8-Dimethoxy-3-methyl-1,10-ethylenealloxazinium chloride (1a) was found to be a superior photooxidation catalyst among substituted ethylene-bridged flavinium salts (R=7,8-diMeO, 7,8-OCH2O-, 7,8-diMe, H, 7,8-diCl, 7-CF3 and 8-CF3). Selection was carried out based on structure vs catalytic activity and properties relationship investigations. Flavinium salt 1a proved to be robust enough for practical applications in benzylic oxidations/oxygenations, which was demonstrated using a series of substrates with high oxidation potential, i. e., 1-phenylethanol, ethylbenzene, diphenylmethane and diphenylmethanol derivatives substituted with electron-withdrawing groups (Cl or CF3). The unique capabilities of 1a can be attributed to its high photostability and participation via a relatively long-lived singlet excited state, which was confirmed using spectroscopic studies, electrochemical measurements and TD-DFT calculations. This allows the maximum use of the oxidation power of 1a, which is given by its singlet excited state reduction potential of +2.4 V. 7,8-Dichloro-3-methyl-1,10-ethylenealloxazinium chloride (1 h) can be used as an alternative photocatalyst for even more difficult substrates. (Figure presented.).
Quinoxalin -2 (1H)-ketone compound and its preparation method and application
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Paragraph 2; 5; 7, (2016/10/10)
The invention relates to a 1-substituted-6-methoxy-7-(3-morpholine propoxy) quinoxaline-2(1H)-ketone compound which is shown as the formula (I), preparation method and an application thereof. The benzodioxole is used as the raw material and subjected to nitration reaction for two times to produce the dinitration product: 5,6-dinitrobenzo[d][1,3] dioxacyclopentane, the 5,6-dinitrobenzo[d][1,3] dioxacyclopentane is subjected to ring opening under conditions of strong alkaline to obtain the ring opening product: 2-methoxy-4,5-dinitrophenol, the 2-methoxy-4,5-dinitrophenol and 4-(3-chloropropyl) morpholine are allowed to perform nucleophilic substitution, so as to obtain 4-(3-(2- methoxy-4,5-dinitrophenoxy) propyl) morpholine, the 4-(3-(2- methoxy-4,5-dinitrophenoxy) propyl) morpholine is reduced and allowed to perform ring closing reaction with ethyl glyoxalate to produce 6-methoxy-7-(3-morpholine propoxy) quinoxaline-2(1H)-ketone, and finally the 6-methoxy-7-(3-morpholine propoxy) quinoxaline-2(1H)-ketone is allowed to react with halogenated hydrocarbon containing substituents R under the alkaline condition, so as to produce the 1-substituted-6-methoxy-7-(3-morpholine propoxy) quinoxaline-2(1H)-ketone compound. The ketone compound has inhibition effect on EGFR kinase.(img file='DDA0000468270950000011.TIF' wi='928' he='416'/).