77510-50-0

Basic information

• Product Name: (R)-3-Hydroxypyrrolidin-2-one
• Synonyms: (R)-3-Hydroxypyrrolidin-2-one;(R)-4-hydroxy-2-oxopyrrolidine;(R)-3-Hydroxy-2-pyrrolidone;(R)-3-Hydroxy-pyrrolidine-2-one;2-Pyrrolidinone, 3-hydroxy-, (3R)-
• CAS NO: 77510-50-0
• Molecular Formula: C₄H₇NO₂
• Molecular Weight: 101.104
• Mol File: 77510-50-0.mol
• Article Data: 7

Chemical Properties

• Melting Point: 100-103℃
• Boiling Point: 364℃
• Flash Point: 174℃
• Appearance: /
• Density: 1.292
• Vapor Pressure: 9.26E-07mmHg at 25°C
• Refractive Index: 1.513
• Storage Temp.: 2-8°C
• PKA: 12.82±0.20(Predicted)
• CAS DataBase Reference: (R)-3-Hydroxypyrrolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-Hydroxypyrrolidin-2-one(77510-50-0)
• EPA Substance Registry System: (R)-3-Hydroxypyrrolidin-2-one(77510-50-0)

Safety Data

• Hazardous Substances Data: 77510-50-0(Hazardous Substances Data)

Usage

General Description

(R)-3-Hydroxypyrrolidin-2-one, also known as (R)-lactamide, is a chemical compound with the molecular formula C5H9NO2. It is a chiral molecule, meaning it has a non-superimposable mirror image, and the (R)-enantiomer is the naturally occurring form. (R)-3-Hydroxypyrrolidin-2-one is widely used in the pharmaceutical industry as a chiral building block and intermediate in the synthesis of various drugs and bioactive compounds. It has also shown potential as a ligand in asymmetric catalysis. Additionally, (R)-3-Hydroxypyrrolidin-2-one has been studied for its antioxidant and anti-inflammatory properties, making it a subject of interest in the development of new therapeutic agents.

InChI:InChI=1/C4H7NO2/c6-3-1-2-5-4(3)7/h3,6H,1-2H2,(H,5,7)/t3-/m1/s1

Upstream product

• 31771-40-1 (R)-β-hydroxy-4-aminobutyric acid 
• 42491-95-2 3-acetoxy-2-pyrrolidinone 
• 34368-52-0 (S)-3-hydroxypyrrolidin-2-one 

Downstream Products

• 99682-03-8 (R)-3-(p-tosyloxy)-2-pyrrolidone 
• 1263404-00-7 (S)-(-)-methyl 3-(4-(5-methyl-1,3,4-oxadiazol-2-yl)phenoxy)-5-((2-oxopyrrolidin-3-yl)oxy)benzoate 
• 1354721-05-3 3-((R)-2-oxo-pyrrolidin-3-yloxy)-benzoic acid methyl ester 

Relevant articles and documents

CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS

The subject matter herein is directed to carbazole-containing amide, carbamate, and urea derivatives and pharmaceutically acceptable salts or hydrates thereof of structural formula I wherein the variable R1, R2, R3, R4, R5, R6, R7, A, D, E, G, J, L, M, Q, a, and b are accordingly described. Also provided are pharmaceutical compositions containing the compounds of formula I to treat a Cry-mediated disease or disorder, such as diabetes, complications associated with diabetes, Cushing's syndrome, NASH, NAFLD, asthma, and COPD.

SUBSTITUTED BENZAMIDE DERIVATIVES AS GLUCOKINASE (GK) ACTIVATORS

The present invention relates to substituted benzamide derivatives of the general Formula I and their pharmaceutically acceptable salts, pharmaceutically acceptable solvates, enantiomers, diastereomers, prodrugs, metabolites, and polymorphs and can be use

Chemoenzymatic enantioselective synthesis of 3-hydroxy-2-pyrrolidinones and 3-hydroxy-2-piperidinones

The enantioselective synthesis of 3-hydroxypyrrolidin-2-ones and 3-hydroxy piperidin-2-ones has been carried out in high enantiomeric excess employing immobilized lipase from Pseudomonas cepacia.