77544-60-6

Basic information

• Product Name: 2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]-1-(p-toluenesulfonyl)-ethanol
• Synonyms: 2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]-1-(p-toluenesulfonyl)-ethanol;Ethanol,2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-, 1-(4-Methylbenzenesulfonate);2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate;2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethyl toluene-4-sulfonate;2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethyl toluenesulfonate;2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethyl tosylate;Monotosylated tetraethylene glycol;Tetraethylene glycol monotosylate
• CAS NO: 77544-60-6
• Molecular Formula: C₁₅H₂₄O₇S
• Molecular Weight: 348.41
• Mol File: 77544-60-6.mol
• Article Data: 120

Chemical Properties

• Boiling Point: 492.5±40.0 °C(Predicted)
• Flash Point: >110℃
• Appearance: /
• Density: 1.202 g/mL at 25 °C
• Refractive Index: n20/D1.507
• Storage Temp.: 2-8°C
• Solubility: Soluble in Water, DMSO, DCM, DMF
• PKA: 14.36±0.10(Predicted)
• CAS DataBase Reference: 2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]-1-(p-toluenesulfonyl)-ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]-1-(p-toluenesulfonyl)-ethanol(77544-60-6)
• EPA Substance Registry System: 2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]-1-(p-toluenesulfonyl)-ethanol(77544-60-6)

Safety Data

• Hazard Codes: T,Xi
• Statements: 25-34-36
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 2927 8(6.1) / PGII
• WGK Germany: 3
• Hazardous Substances Data: 77544-60-6(Hazardous Substances Data)

Usage

Description

2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]-1-(p-toluenesulfonyl)-ethanol, also known as PEG5-Tos, is a PEG linker containing a hydroxyl group with a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media, while the hydroxyl group allows for further derivatization or replacement with other reactive functional groups. The tosyl group serves as an excellent leaving group for nucleophilic substitution reactions.

Uses

Used in Pharmaceutical Industry:
PEG5-Tos is used as a building block for the synthesis of various pharmaceutical compounds. Its hydrophilic PEG spacer enhances the solubility and bioavailability of the resulting compounds, while the hydroxyl group allows for the attachment of various functional groups to improve their therapeutic properties.
Used in Chemical Synthesis:
PEG5-Tos is used as an intermediate in the synthesis of various organic compounds. Its hydroxyl group can be easily derivatized or replaced with other reactive functional groups, making it a versatile building block for the development of new molecules with specific properties.
Used in Bioconjugation:
PEG5-Tos is used as a linker in bioconjugation processes, where it can be attached to biomolecules such as proteins, peptides, or nucleic acids. The hydrophilic PEG spacer improves the solubility and stability of the conjugates, while the hydroxyl group allows for the attachment of various functional groups to modulate their properties.
Used in Drug Delivery Systems:
PEG5-Tos is used in the development of drug delivery systems, where it can be incorporated into nanoparticles, liposomes, or hydrogels to improve the solubility, stability, and targeted delivery of therapeutic agents. The hydroxyl group can be used to attach drugs or other functional groups to the delivery system, while the tosyl group can be used for further derivatization or crosslinking.

Upstream product

• 112-60-7 Tetraethylene glycol 
• 98-59-9 p-toluenesulfonyl chloride 
• 104-15-4 toluene-4-sulfonic acid 
• 112-27-6 2,2'-[1,2-ethanediylbis(oxy)]bisethanol 
• 37860-51-8 tetraethylene glycol di(p-toluenesulfonate) 
• 2615-15-8 pentaethylene glycol 
• 96922-86-0 1,21-diphenyl-2,5,8,11,14,17,20-heptaoxahenicosane 

Downstream Products

• 36366-93-5 2-<2-<2-(2-phenoxyethoxy)ethoxy>ethoxy>ethanol 
• 128134-70-3 1-hydroxy-11-(4'-nitrophenoxy)-3,6,9-trioxaundecane 
• 134881-76-8 1,4-bis<2-<2-<2-(2-hydroxyethoxy)ethoxy>ethoxy>ethoxy>benzene 
• 188915-75-5 11-acryloxy-3,6,9-trioxa-undecyl tosylate 
• 86259-89-4 2-(2-(2-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethoxy)ethyl 4-methylbenzenesulfonate 
• 224298-57-1 4,4'-bis<2-<2-<2-(2-hydroxyethoxy)ethoxy>ethoxy>ethoxy>azobenzene 
• 223611-40-3 1,1,1-triphenyl-2,5,8,11-tetraoxatridecan-13-yl 4-methylbenzenesulfonate 
• 85141-94-2 2-{2-[2-(2-bromoethoxy)ethoxy]ethoxy}ethan-1-ol 
• 264124-13-2 1-benzyloxy-4-[2-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}ethoxy]benzene 
• 264124-10-9 1-[2-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}ethoxy]-4-triphenylmethylbenzene 
• 313946-56-4 tetraethylene glycol 2-bromoacetate tosylate 
• 333382-87-9 2-(2-(2-(2-(4-bromophenoxy)ethoxy)ethoxy)ethoxy)ethan-1-ol 
• 677746-03-1 1,4-diiodo-2,5-bis(11-hydroxy-3,6,9-trioxaundecyl)benzene 
• 852806-19-0 2-[2-(2-{2-[2-bromo-6-(2-methoxy-benzyl)-phenoxy]-ethoxy}-ethoxy)-ethoxy]-ethanol 

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