77555-27-2

Basic information

• Product Name: 2-(2-PYRIDYLTHIO)ETHAN-1-OL
• Synonyms: 2-(2-PYRIDYLTHIO)ETHAN-1-OL;2-(2-PYRIDYTHIO)ETHAN-1-OL;2-(PYRIDIN-2-YLTHIO)ETHANOL
• CAS NO: 77555-27-2
• Molecular Formula: C₇H₉NOS
• Molecular Weight: 155.22
• Mol File: 77555-27-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 107 °C
• Flash Point: 135.1 °C
• Appearance: /
• Density: 1.21 g/cm³
• Vapor Pressure: 0.000519mmHg at 25°C
• Refractive Index: 1.596
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 2-(2-PYRIDYLTHIO)ETHAN-1-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-PYRIDYLTHIO)ETHAN-1-OL(77555-27-2)
• EPA Substance Registry System: 2-(2-PYRIDYLTHIO)ETHAN-1-OL(77555-27-2)

Safety Data

• Hazardous Substances Data: 77555-27-2(Hazardous Substances Data)

Usage

General Description

2-(2-Pyridylthio)ethan-1-ol, also known as 2-mercaptoethanol (2-ME), is a chemical compound with the formula C6H7NS. It is an organosulfur compound that contains a pyridylthio group, which consists of a pyridine ring attached to a thiol group. 2-mercaptoethanol is commonly used as a reducing agent in biochemistry and molecular biology, where it is used to break disulfide bonds in proteins. It is also used as a stabilizer for certain enzymes and as a protective agent against radiation damage in biological samples. Additionally, it is used as a metal chelator in certain industrial processes, and as a component of some pharmaceutical and cosmetic products. However, it is important to handle 2-mercaptoethanol with caution, as it has a strong and unpleasant odor and can be irritating to the skin, eyes, and respiratory system.

InChI:InChI=1/C7H9NOS/c9-5-6-10-7-3-1-2-4-8-7/h1-4,9H,5-6H2

Upstream product

• 109-04-6 2-bromo-pyridine 
• 60-24-2 2-hydroxyethanethiol 
• 2637-34-5 2-Sulfanylpyridine 
• 107-07-3 2-chloro-ethanol 
• 109-09-1 2-chloropyridine 
• 540-51-2 2-bromoethanol 

Relevant articles and documents

THIAZOLIDINONE COMPOUNDS AND USE THEREOF

A pharmaceutical composition containing a compound of Formula (I) for treating an opioid receptor-associated condition. Also disclosed is a method for treating an opioid receptor-associated condition using such a compound. Further disclosed are two sets of thiazolidinone compounds of formula (I): (i) compounds each having an enantiomeric excess greater than 90% and (ii) compounds each being substituted with deuterium.

2-PROPENE-1-ONES AS HSP 70 INDUCERS

The present invention relates to novel compounds of 2-propene-1-one series, of general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them, wherein R5, R6, Q and Y are as defined in the specification. The present invention also relates to a process for preparing such compounds, compositions containing such compounds, and use of such compound and composition in medicine. The compounds of the general formula (I) induce HSP-70 and are useful for the treatment of diseases accompanying pathological stress in a living mammalian organism, including a human being, such as stroke, myocardial infarction, inflammatory disorder, hepatotoxicity, sepsis, diseases of viral origin, allograft rejection, tumourous diseases, gastric mucosal damage, brain haemorrhage, endothelial dysfunctions, diabetic complications, neuro-degenerative diseases, post-traumatic neuronal damage, acute renal failure, glaucoma and aging related skin degeneration.

ETUDE DES REACTIONS DE SRN1-PARTIE 10 ACTION DE SULFANIONS SUR LES HALOGENURES D'ARYLE FONCTIONNALISES. SYNTHESE DIRECTE DE BENZOTHIOPHENES ET THIENOPYRIDINES

Functionalized aromatic halides Ar1XY (Ar1=C6H4, Y=OCH3,CONH2,CN,COCH3,CHO,COC6H5) undergo SRN1 reactions with sulphur anions -SR, either simple (R=C2H5,CH2C6H5) or functionalized (R=(CH2)2OH,(CH2)2CO2Et,CH2CO2Et).Products Ar1YS- formed from the fragmentation of the radical anion Ar1YSR- are related to the redox potential of the aryl moiety Ar1Y and with the energy of the bond S-R.In the heterocyclic series (Ar2=pyridine, Ar3=quinoline) a similar relationship appears but a competitive SN(AR) reaction occurs for pyridine substrates bearing an electron withdrawing group.A direct synthesis of benzothiophen via SRN1 reaction and an improved synthesis of thienopyridines based on the SN(Ar) reaction are reported.