7761-30-0 Usage
Description
2-(4-FLUOROBENZOYL)ACETIC ACID, also known as 4-Fluoro-a-oxo-benzenepropanoic Acid, is an organic compound with the molecular formula C9H7FO3. It is a derivative of acetic acid, featuring a fluorobenzoyl group attached to the acetic acid backbone. 2-(4-FLUOROBENZOYL)ACETIC ACID has potential applications in the pharmaceutical industry due to its unique chemical structure and properties.
Uses
Used in Pharmaceutical Industry:
2-(4-FLUOROBENZOYL)ACETIC ACID is used as a chemical intermediate for the synthesis of serine/threonine kinase inhibitors. These inhibitors play a crucial role in treating various diseases by targeting and modulating the activity of specific kinases, which are often dysregulated in pathological conditions.
As a Serine/Threonine Kinase Inhibitor:
2-(4-FLUOROBENZOYL)ACETIC ACID is used as a serine/threonine kinase inhibitor for the development of therapeutic agents to treat diseases associated with the dysregulation of these kinases. By inhibiting the activity of these enzymes, the compound can potentially help in the management and treatment of conditions such as cancer, autoimmune disorders, and neurological diseases.
In Drug Development:
2-(4-FLUOROBENZOYL)ACETIC ACID serves as a key building block in the design and synthesis of novel drug candidates targeting serine/threonine kinases. Its unique chemical structure allows for the development of highly specific and potent inhibitors, which can be further optimized for improved efficacy, selectivity, and pharmacokinetic properties.
In Research and Development:
2-(4-FLUOROBENZOYL)ACETIC ACID is also used in academic and industrial research settings to study the structure-activity relationships of serine/threonine kinase inhibitors. By understanding the interactions between 2-(4-FLUOROBENZOYL)ACETIC ACID and its target kinases, researchers can gain valuable insights into the design of more effective and safer therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 7761-30-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,7,6 and 1 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 7761-30:
(6*7)+(5*7)+(4*6)+(3*1)+(2*3)+(1*0)=110
110 % 10 = 0
So 7761-30-0 is a valid CAS Registry Number.
7761-30-0Relevant articles and documents
Bio-inspired enantioselective full transamination using readily available cyclodextrin
Zhang, Shiqi,Li, Guangxun,Liu, Hongxin,Wang, Yingwei,Cao, Yuan,Zhao, Gang,Tang, Zhuo
, p. 4203 - 4208 (2017/02/05)
The mimics of vitamin B6-dependent enzymes that catalyzed an enantioselective full transamination in the pure aqueous phase have been realized for the first time through the establishment of a new “pyridoxal 5′-phosphate (PLP) catalyzed non-covalent cyclodextrin (CD)-keto acid inclusion complexes” system, and various optically active amino acids have been obtained.
SERINE/THREONINE KINASE INHIBITORS
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, (2015/07/16)
Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such diseases, or associated pathological conditions are disclosed.
D-amino acid dehydrogenase and method of making D-amino acids
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Page/Page column 6, (2008/12/07)
Polypeptides capable of catalyzing the reductive amination of a 2-ketoacid to its corresponding D-amino acid are provided. The polypeptides can be prepared by mutagenesis of, e.g., a diaminopimelate dehydrogenase. Also provided is a method of making a D-amino acid using a catalytically active polypeptide, wherein a 2-ketoacid is allowed to contact the polypeptide in the presence of a nicotinamide cofactor and ammonia or an ammonia source.
