776297-01-9

Basic information

• Product Name: ethyl 2-benzyl-3-oxo-3-(thiophen-2-yl)propanoate
• Synonyms: ethyl 2-benzyl-3-oxo-3-(thiophen-2-yl)propanoate
• CAS NO: 776297-01-9
• Molecular Weight: 288.367
• Mol File: 776297-01-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: ethyl 2-benzyl-3-oxo-3-(thiophen-2-yl)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-benzyl-3-oxo-3-(thiophen-2-yl)propanoate(776297-01-9)
• EPA Substance Registry System: ethyl 2-benzyl-3-oxo-3-(thiophen-2-yl)propanoate(776297-01-9)

Safety Data

• Hazardous Substances Data: 776297-01-9(Hazardous Substances Data)

Upstream product

• 13669-10-8 ethyl 2-thenoylacetate 
• 100-39-0 benzyl bromide 
• 1202634-50-1 ethyl 2-(2-thiophenecarbonyl)-3-phenylacrylate 
• 591-50-4 iodobenzene 
• 620-79-1 Ethyl 2-benzylacetoacetate 
• 301164-69-2 (1H-benzo[d][1,2,3]triazol-1-yl)(thiophen-2-yl)methanone 
• 100-44-7 benzyl chloride 

Downstream Products

• 109399-10-2 4-benzyl-2-(1-methyl-[4]piperidyl)-5-[2]thienyl-1,2-dihydro-pyrazol-3-one 

Relevant articles and documents

Catalytic asymmetric construction of C-4 alkenyl substituted pyrazolone derivatives bearing multiple stereoelements

An organocatalytic asymmetric process was reported for the sterically precise construction of C-4 alkenyl substituted pyrazolone derivatives bearing multiple stereoelements. A series of interesting products featuring the union of a centrally chiral pyrazolone moiety and an axially chiral styrene unit were obtained in high yield with excellent diastereoselectivity and enantioselectivity (up to 99% ee, >20?:?1 dr). The process has the characteristics of mild reaction conditions, simple operation and broad substrate scope. The result of gram-scale reaction indicates that the reaction has good practicability.

Enantioselective and Diastereoselective Ir-Catalyzed Hydrogenation of α-Substituted β-Ketoesters via Dynamic Kinetic Resolution

An iridium/f-amphol catalytic system for the enantioselective hydrogenation of α-substituted β-ketoesters via dynamic kinetic resolution is reported. The desired anti products were obtained in high yields (up to 98%) with good diastereoselectivity (up to 96:4 diastereometic ratio (dr)) and excellent enantioselectivity (up to >99% enantiomeric excess (ee)). A catalytic model is proposed to explain the stereoselectivity.

Heck reaction of Baylis-Hillman adducts with iodobenzenes using a catalytic amount of Pd/C under solvent-free conditions

The reaction of Baylis-Hillman adducts with iodobenzenes using commercially available palladium-on-carbon as a catalyst under solvent-free conditions afforded the corresponding coupling products, α-benzyl-β-keto esters, in high to excellent yields. The reactions are very efficient.