77679-27-7Relevant articles and documents
Polymer-supported radiopharmaceuticals: [131I]MIBG and [123I]MIBG
Hunter, Duncan H.,Zhu, Xizhen
, p. 653 - 661 (1999)
A new method has been developed that produces no-carrier-added [131I]MIBG in ≥ 90% radiochemical yield and high chemical purity. Isolation and purification are simple involving just filtration and absorption and desorption onto a C18 Sep-Pak(TM) cartridge. No-carrier-added material should avoid the potential pharmacological side effects accompanying the current method of production.
A tin precursor for the synthesis of no-carrier-added [*I]MIBG and [211At]MABG
Vaidyanathan, Ganesan,Affleck, Donna J.,Alston, Kevin L.,Zalutsky, Michael R.
, p. 177 - 182 (2007)
Radioiodinated MIBG has shown considerable promise as an imaging agent for cardiac and oncologic applications, and also as a targeted radio therapeutic for treating patients with neuroendocrine tumors. This radiolabeled agent, synthesized at a no-carrier-
Radioactive iodine labeling method
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Paragraph 0112; 0113; 0114; 0117; 0118, (2017/07/23)
The invention discloses a radioactive iodine labeling method. Ar-B(OH)2 is allowed to react with NaI in a reaction solvent in the presence of a copper coordination compound so as to obtain Ar-I, so radioactive iodine labeling is realized. The method
A Highly Efficient Copper-Mediated Radioiodination Approach Using Aryl Boronic Acids
Zhang, Pu,Zhuang, Rongqiang,Guo, Zhide,Su, Xinhui,Chen, Xiaoyuan,Zhang, Xianzhong
, p. 16783 - 16786 (2016/11/17)
A convenient and quantitative radioiodination method by copper-mediated cross-coupling of aryl boronic acids was developed. The mild labeling conditions, ready availability of the boronic acid substrate, simple operation, broad functional group tolerance and excellent radiochemical yield (RCY) make this a practical strategy for radioiodine labeling without further purification.