77876-39-2 Usage
Description
(2S,4S)-(-)-2,4-BIS(DIPHENYLPHOSPHINO)PENTANE, also known as Josiphos, is a chiral phosphine ligand that exists as a white crystalline powder. It is characterized by its specific stereochemistry, with the 2S,4S configuration, and features two diphenylphosphino groups attached to a pentane backbone. This unique structure endows it with valuable properties in catalysis and asymmetric synthesis.
Uses
Used in Pharmaceutical Industry:
(2S,4S)-(-)-2,4-BIS(DIPHENYLPHOSPHINO)PENTANE is used as a ligand for asymmetric hydrogenation reactions in the pharmaceutical industry. Its application is crucial for the production of enantiomerically pure compounds, which are essential for the development of many drugs with improved efficacy and reduced side effects.
Used in Chemical Synthesis:
In the field of chemical synthesis, (2S,4S)-(-)-2,4-BIS(DIPHENYLPHOSPHINO)PENTANE is employed as a ligand for various asymmetric catalytic reactions, including the hydrogenation of ketones and alkenes. Its use contributes to the synthesis of chiral compounds with high enantioselectivity and yield, which is vital for the production of specialty chemicals and fine chemicals.
Used in Research and Development:
(2S,4S)-(-)-2,4-BIS(DIPHENYLPHOSPHINO)PENTANE is also utilized in research and development settings for the study of asymmetric catalysis and the development of new synthetic methods. Its unique properties make it a valuable tool for chemists working on the design and optimization of enantioselective reactions.
Check Digit Verification of cas no
The CAS Registry Mumber 77876-39-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,7,8,7 and 6 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 77876-39:
(7*7)+(6*7)+(5*8)+(4*7)+(3*6)+(2*3)+(1*9)=192
192 % 10 = 2
So 77876-39-2 is a valid CAS Registry Number.
InChI:InChI=1/C29H30P2/c1-24(30(26-15-7-3-8-16-26)27-17-9-4-10-18-27)23-25(2)31(28-19-11-5-12-20-28)29-21-13-6-14-22-29/h3-22,24-25H,23H2,1-2H3/t24-,25-/m0/s1
77876-39-2Relevant articles and documents
Ni-Catalyzed enantioselective reductive arylcyanation/cyclization of: N -(2-iodo-aryl) acrylamide
Dong, Kaiwu,Ren, Xinyi,Shen, Chaoren,Wang, Guangzhu
, p. 1135 - 1138 (2022/02/03)
A Ni/(S,S)-BDPP-catalyzed intramolecular Heck cyclization of N-(2-iodo-aryl) acrylamide with 2-methyl-2-phenylmalononitrile was developed to give oxindoles with good enantioselectivities. We found that utilizing such an electrophilic cyanation reagent cou
Electronic and steric effects of ligands as control elements for rhodium-catalyzed asymmetric hydrogenation
Herseczki, Zsanett,Gergely, Ildiko,Hegedues, Csaba,Szoellosy, Aron,Bakos, Jozsef
, p. 1673 - 1676 (2007/10/03)
Chiral diphosphine ligands analogous to bdpp have been synthesized and tested in order to study the effect of the electronic nature of the ligands in Rh-catalyzed asymmetric hydrogenation of some prochiral olefins. The results are compared with those obtained with the analogous unsubstituted ligand (bdpp). The rhodium-catalyzed asymmetric hydrogenation of olefins was influenced by ligand-based electronic effects, as well as substrate based ones. Excellent ee's (up to 98.3%) have been obtained in the rhodium-catalyzed hydrogenation of (Z)-α-acetamidocinnamic acids and esters.
Process for producing optically active benzhydrol compounds
-
, (2008/06/13)
A process for producing a benzhydrol compound (II) which comprises hydrogenating a benzophenone compound (I) in the presence of a hydrogenation catalyst consisting of a transition metal complex, a base and an optically active diamine compound: STR1 wherein R1 to R10 each represents H, OH, C1-4 alkyl, C1-4 alkoxy, C1-4 alkanoyl, etc., R2 and R3, and R8 and R9 may form --CH=CH--CH=CH--, or any two of R1 to R9 adjacent to each other may be bonded to thereby form --OCH2 O-- or --(CH2)3 --. By using this process, optically active benzhydrol compounds which have a high purity and are useful as, for example, intermediates in the synthesis of drugs can be produced by simple procedures.