77887-20-8

Basic information

• Product Name: Uridine, 2'-deoxy-5-(phenylethynyl)-
• Synonyms: Uridine, 2'-deoxy-5-(phenylethynyl)-;2'-deoxy-5-(phenylethynyl)Uridine
• CAS NO: 77887-20-8
• Molecular Formula: C₁₇H₁₆N₂O₅
• Molecular Weight: 328.322
• Mol File: 77887-20-8.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Density: 1.49±0.1 g/cm3(Predicted)
• PKA: 8.25±0.10(Predicted)
• CAS DataBase Reference: Uridine, 2'-deoxy-5-(phenylethynyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Uridine, 2'-deoxy-5-(phenylethynyl)-(77887-20-8)
• EPA Substance Registry System: Uridine, 2'-deoxy-5-(phenylethynyl)-(77887-20-8)

Safety Data

• Hazardous Substances Data: 77887-20-8(Hazardous Substances Data)

Usage

General Description

Uridine, 2'-deoxy-5-(phenylethynyl)- is a modified nucleoside that consists of a uracil base linked to a deoxyribose sugar and a phenylethynyl group attached at the 5' position. This chemical is commonly used in biochemical research as a molecular probe to study RNA structure and function, as well as in the development of novel oligonucleotide-based therapeutics. It has also been studied for its potential neuroprotective and cognitive-enhancing effects, making it a topic of interest in the field of neuroscience and neuropharmacology. The modification of uridine with the phenylethynyl group may alter its interactions with other molecules and biological processes, leading to the exploration of its potential applications in various therapeutic and research areas.

Upstream product

• 77875-92-4 C₃₃H₂₈N₂O₇ 
• 78824-34-7 5-Phenylethynyl-1-((2R,4S,5R)-4-trimethylsilanyloxy-5-trimethylsilanyloxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione 
• 536-74-3 phenylacetylene 
• 151361-85-2 5-(Trifluoromethanesulfonyloxy)-2'-deoxyuridine 
• 54-42-2 5-Iodo-2'-deoxyuridine 
• 943446-57-9 C₂₁H₂₀N₂O₇ 
• 1956-30-5 3',5'-O-diacetyl-5-iodo-2'-deoxyuridine 
• 5168-36-5 5-hydroxy-2'-deoxyuridine 
• 78824-31-4 di-O-trimethylsilyl-5-iodo-2'-deoxyuridine 
• 31356-86-2 1-[2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-5-iodouracil 

Downstream Products

• 319425-61-1 3-(2′-deoxy-β-D-ribofuranosyl)-6-(phenyl)-2,3-dihydrofuro-[2,3-d]pyrimidin-2-one 
• 946148-16-9 5-phenylethynyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)uridine 

Relevant articles and documents

Efficient sonogashira coupling of unprotected halonucleosides in aqueous solvents using water-soluble palladium catalysts

A variety of applications of C-alkynylated nucleosides has prompted the continuing development of efficient synthetic methods for their preparation. We report an efficient and environmentally benign Sonogashira coupling reaction for alkynylation of unprotected halonucleosides in an aqueoussolvent. The combination of Pd(OAc)2, CuI, and TXPTS [trisodium tri(2,4-dimethyl-5-sulfonatophenyl)phosphane] provided an effective catalyst for the alkynylation of 8-bromo-purines and 5-iodouridine in H2O/CH 3CN (1:1) in yields ranging from 42 to 98%.

Design and studies of novel 5-substituted alkynylpyrimidine nucleosides as potent inhibitors of mycobacteria

We herein report a new category of 5-substituted pyrimidine nucleosides as potent inhibitors of mycobacteria. A series of 5-alkynyl derivatives of 2′-deoxyuridine (1-8), 2′-deoxycytidine (9-14), uridine (15-17), and 2′-O-methyluridine (18, 19) were synthe

Palladium-catalyzed coupling of terminal alkynes with 5-(trifluoromethanesulfonyloxy) pyrimidine nucleosides

-