78016-96-3

Basic information

• Product Name: 1H-Imidazole-4,5-dicarboxylic acid, 2-(trifluoromethyl)-
• Synonyms: 2-(trifluoroMethyl)-1H-iMidazole-4,5-dicarboxylic acid;1H-Imidazole-4,5-dicarboxylic acid, 2-(trifluoromethyl)-
• CAS NO: 78016-96-3
• Molecular Formula: C6H3F3N2O4
• Molecular Weight: 224.09
• Mol File: 78016-96-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 220-223 °C (decomp)
• Boiling Point: 480.2±45.0 °C(Predicted)
• Appearance: /
• Density: 1.874±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 2.25±0.10(Predicted)
• CAS DataBase Reference: 1H-Imidazole-4,5-dicarboxylic acid, 2-(trifluoromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Imidazole-4,5-dicarboxylic acid, 2-(trifluoromethyl)-(78016-96-3)
• EPA Substance Registry System: 1H-Imidazole-4,5-dicarboxylic acid, 2-(trifluoromethyl)-(78016-96-3)

Safety Data

• Hazardous Substances Data: 78016-96-3(Hazardous Substances Data)

Usage

General Description

1H-Imidazole-4,5-dicarboxylic acid, 2-(trifluoromethyl)-, also known as TFMIDA, is a chemical compound with the molecular formula C7H4F3N3O4. It is a derivative of imidazole and is primarily used as a building block in the synthesis of pharmaceuticals and agrochemicals. TFMIDA is known for its strong acidity and its ability to chelate metal ions, making it useful in various chemical reactions and as a potential ligand in coordination chemistry. It is also used in the development of new materials and in medicinal chemistry research for the synthesis of bioactive molecules. Additionally, TFMIDA is considered to have potential applications in organic synthesis, due to its unique chemical properties.

Upstream product

• 312-73-2 2-Trifluoromethylbenzimidazole 

Downstream Products

• 78016-98-5 2-(trifluoromethyl)-1H-imidazole-5-carboxylic acid 

Relevant articles and documents

PDE10 MODULATORS

The present invention relates to compounds of formula (I) wherein R1, R2, R3, R5, W, X, X1, Y, Y1, Z and Z1 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit PDE10A and can be used in the treatment of CNS disorders such as schizophrenia, Alzheimer's disease, and Parkinson's disease.

2-TRIFLUOROMETHYLIMIDAZOLE, 2,4,5-TRIS(TRIFLUOROMETHYL)IMIDAZOLE AND RELATED COMPOUNDS

2-Trifluoromethylimidazole, prepared by the reaction of imidazole-2-carboxylic acid with sulphur tetrafluoride, afforded a silver salt which reacted with organohalides (bromomethane, ethyl bromoacetate, N,N-dimethyl-2-chloroethylamine, and chloroacetonitrile) to give the corresponding N-alkylated derivatives. 2-Trifluoromethylimidazole-4,5-dicarboxylic acid was obtained by oxidation of 2-trifluoromethylbenzimidazole, and on decarboxylation gave only traces of 2-trifluoromethylimidazole; the major product was 2-trifluoromethylimidazole-4-carboxylic acid.The di-acid and sulphur tetrafluoride gave 2,4,5-tris(trifluoromethyl)imidazole.