780785-13-9

Basic information

• Product Name: 5-dimethylcarbamoyl-2-(toluene-4-sulfonylamino)methyl-3,4-dihydro-2H-pyridine-1-carboxylic acid methyl ester
• Synonyms: 5-dimethylcarbamoyl-2-(toluene-4-sulfonylamino)methyl-3,4-dihydro-2H-pyridine-1-carboxylic acid methyl ester
• CAS NO: 780785-13-9
• Molecular Weight: 395.48
• Mol File: 780785-13-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-dimethylcarbamoyl-2-(toluene-4-sulfonylamino)methyl-3,4-dihydro-2H-pyridine-1-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-dimethylcarbamoyl-2-(toluene-4-sulfonylamino)methyl-3,4-dihydro-2H-pyridine-1-carboxylic acid methyl ester(780785-13-9)
• EPA Substance Registry System: 5-dimethylcarbamoyl-2-(toluene-4-sulfonylamino)methyl-3,4-dihydro-2H-pyridine-1-carboxylic acid methyl ester(780785-13-9)

Safety Data

• Hazardous Substances Data: 780785-13-9(Hazardous Substances Data)

Upstream product

• 780784-69-2 (S)-2-cyano-5-dimethylcarbamoyl-2H-pyridine-1-carboxylic acid methyl ester 
• 780785-11-7 2-cyano-5-dimethylcarbamoyl-3,4-dihydro-2H-pyridine-1-carboxylic acid methyl ester 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 780785-17-3 2-(toluene-4-sulfonyl)octahydropyrido[1,2-a]pyrazine-7-carboxylic acid dimethylamide 
• 780785-23-1 [2-(toluene-4-sulfonyl)octahydropyrido[1,2-a]pyrazine-7-yl]methanol 
• 156856-52-9 (7R,9AS)-Trans-7-(hydroxymethyl)-2-(tert-butoxycarbonyl)-2,3,4,6,7,8,9,9a-octahydro-1H-pyrido[1,2-a]pyrazine 
• 764714-59-2 ((7R,9aS)-octahydro-1H-pyrido[1,2-a]pyrazin-7-yl)methanol 
• 780785-15-1 6-(toluene-4-sulfonylamino)methyl-1,4,5,6-tetrahydropyridine-3-carboxylic acid dimethylamide 

Relevant articles and documents

New entries in Lewis acid-Lewis base bifunctional asymmetric catalyst: Catalytic enantioselective Reissert reaction of pyridine derivatives

The first catalytic enantioselective Reissert reaction of pyridine derivatives that affords products with excellent regio- and enantioselectivity is described. The key for success is the development of new Lewis acid-Lewis base bifunctional asymmetric catalysts containing an aluminum as a Lewis acid and sulfoxides or phosphine sulfides as a Lewis base. These reactions are useful for the synthesis of a variety of chiral piperidine subunits, and catalytic enantioselective formal synthesis of CP-293,019, a selective D4 receptor antagonist, was achieved. Preliminary mechanistic studies indicated that both sulfoxides and phosphine sulfides can activate TMSCN as a Lewis base. In addition, the sulfoxides with appropriate stereochemistry might stabilize a highly enantioselective bimetallic complex (a presumed active catalyst) through internal coordination to aluminum. Copyright