78097-09-3 Usage
Description
1-(2-HYDROXY-ETHOXYMETHYL)-5-TRIFLUOROMETHYL-1H-PYRIMIDINE-2,4-DIONE is a synthetic pyrimidine derivative characterized by the presence of a trifluoromethyl group and a hydroxy-ethoxymethyl functional group. 1-(2-HYDROXY-ETHOXYMETHYL)-5-TRIFLUOROMETHYL-1H-PYRIMIDINE-2,4-DIONE exhibits potential biological activity and may offer pharmacological benefits such as enhanced lipophilicity and metabolic stability. Its structural features also suggest the possibility of hydrogen bonding and interactions with biological systems, making it a compound of interest for various applications in medicinal chemistry, drug discovery, agrochemicals, and materials science.
Uses
Used in Medicinal Chemistry:
1-(2-HYDROXY-ETHOXYMETHYL)-5-TRIFLUOROMETHYL-1H-PYRIMIDINE-2,4-DIONE is used as a compound in medicinal chemistry for its potential to interact with biological systems due to its hydroxy-ethoxymethyl group, which may facilitate hydrogen bonding and other interactions.
Used in Drug Discovery:
In the field of drug discovery, 1-(2-HYDROXY-ETHOXYMETHYL)-5-TRIFLUOROMETHYL-1H-PYRIMIDINE-2,4-DIONE is utilized as a starting material or a structural component in the development of new pharmaceuticals, taking advantage of its potential biological activity and pharmacological properties.
Used in Agrochemicals:
1-(2-HYDROXY-ETHOXYMETHYL)-5-TRIFLUOROMETHYL-1H-PYRIMIDINE-2,4-DIONE is used as a compound in the agrochemical industry, possibly for the development of new pesticides or other agricultural chemicals,得益于其潜在的生物活性和化学稳定性。
Used in Materials Science:
Within materials science, 1-(2-HYDROXY-ETHOXYMETHYL)-5-TRIFLUOROMETHYL-1H-PYRIMIDINE-2,4-DIONE may be employed in the design and synthesis of novel materials, potentially leveraging its structural properties and interactions with biological systems for specific applications.
Check Digit Verification of cas no
The CAS Registry Mumber 78097-09-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,8,0,9 and 7 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 78097-09:
(7*7)+(6*8)+(5*0)+(4*9)+(3*7)+(2*0)+(1*9)=163
163 % 10 = 3
So 78097-09-3 is a valid CAS Registry Number.
78097-09-3Relevant articles and documents
Inhibition of hepatitis B virus (HBV) replication by pyrimidines bearing an acyclic moiety: Effect on wild-type and mutant HBV
Semaine, Wassila,Johar, Monika,Tyrrell, D. Lorne J.,Kumar, Rakesh,Agrawal
, p. 2049 - 2054 (2007/10/03)
Chronic hepatitis B virus (HBV) infection remains a major health problem worldwide. The main clinical limitation of a current antiviral drug for HBV, lamivudine, is the emergence of drug-resistant viral strains upon prolonged therapy. A group of 5-, 6-, or 5,6-substituted acyclic pyrimidine nucleosides with a 1-[(2-hydroxyethoxy)methyl] moiety were synthesized and evaluated for antiviral activities. The target compounds were prepared by the reaction of silylated uracils possessing a variety of substituents at the C-5 or C-6 positions or both with 1,3-dioxolane in the presence of potassium iodide and chlorotrimethylsilane by a convenient and single-step synthesis. Among the compounds tested, 5-chloro and 5-bromo analogues possessing an acyclic glycosyl moiety were the most effective and selective antiviral agents in the in vitro assays against wild-type duck HBV (EC50 = 0.4-2.2 and 3.7-18.5 μM, respectively) and human HBV-containing 2.2.15 cells (EC50 = 4.5-45.4 and 18.5-37.7 μM, respectively). These compounds were also found to retain sensitivity against lamivudine-resistant HBV containing a single mutation (M204I) and double mutations (L180M/M204V). The compounds investigated did not show cytotoxicity to host HepG2 and Vero cells, up to the highest concentration tested. The results presented here confirm and accentuate the potential of acyclic pyrimidine nucleosides as anti-HBV agents and extend our previous observations. We herein report the capability of acyclic pyrimidine nucleosides to inhibit the replication of both wild-type and drug-resistant mutant HBV.
