78238-13-8

Basic information

• Product Name: ethyl 3-methoxy-5-nitrobenzoate
• Synonyms: ethyl 3-methoxy-5-nitrobenzoate;3-Methoxy-5-nitrobenzoic acid methyl ester
• CAS NO: 78238-13-8
• Molecular Formula: C₉H₉NO₅
• Molecular Weight: 211.17
• Mol File: 78238-13-8.mol
• Article Data: 12

Chemical Properties

• Melting Point: 88-90℃
• Boiling Point: 343℃
• Flash Point: 163℃
• Appearance: /
• Density: 1.294
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: ethyl 3-methoxy-5-nitrobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-methoxy-5-nitrobenzoate(78238-13-8)
• EPA Substance Registry System: ethyl 3-methoxy-5-nitrobenzoate(78238-13-8)

Safety Data

• Hazardous Substances Data: 78238-13-8(Hazardous Substances Data)

Usage

General Description

Ethyl 3-methoxy-5-nitrobenzoate is a chemical compound with the molecular formula C10H11NO5. It is a pale yellow solid that is commonly used in the synthesis of pharmaceuticals and organic compounds. ethyl 3-methoxy-5-nitrobenzoate is an ester, which means it is formed through the reaction between an alcohol and a carboxylic acid. It is commonly used as an intermediate in the production of various drugs and as a flavor and fragrance ingredient. Ethyl 3-methoxy-5-nitrobenzoate is also known for its mild, sweet, and fruity odor, making it useful in the manufacturing of perfumes and other scented products. However, it is important to handle this chemical with care, as prolonged exposure can lead to skin and eye irritation.

Upstream product

• 186581-53-3 diazomethane 
• 78238-12-7 3-methoxy-5-nitrobenzoic acid 
• 67-56-1 methanol 
• 2702-58-1 methyl 3,5-dinitrobenzoate 
• 78238-14-9 3-hydroxy-5-nitrobenzoic acid 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 55076-32-9 methyl 3-hydroxy-5-nitrobenzoate 
• 618-71-3 ethyl 3,5-dinitrobenzoate 
• 865-34-9 lithium methanolate 
• 99-34-3 3,5-dinitrobenzoic acid 

Downstream Products

• 78238-12-7 3-methoxy-5-nitrobenzoic acid 
• 78238-14-9 3-hydroxy-5-nitrobenzoic acid 
• 292635-40-6 3-methoxy-5-nitrobenzamide 
• 56709-74-1 methyl 3-bromo-2,6-dinitro-5-methoxybenzoate 
• 883554-93-6 methyl 5-bromo-2-nitro-3-methoxybenzoate 
• 78238-03-6 3-methoxy-5-acetylaminobenzoic acid 
• 78238-07-0 methyl 3-methoxy-5-acetylaminobenzoate 
• 78238-05-8 2-nitro-3-methoxy-5-aminobenzoic acid 
• 78238-06-9 methyl ester of 2-nitro-3-methoxy-5-aminobenzoic acid 
• 78238-04-7 2-nitro-3-methoxy-5-acetylaminobenzoic acid 
• 343220-53-1 3-bromo-2,6-dinitro-5-methoxybenzoic acid 
• 78238-10-5 2,6-dinitro-3-methoxy-5-aminobenzoic acid 
• 78238-08-1 2,6-dinitro-3-methoxy-5-acetylaminobenzoic acid 
• 78238-09-2 methyl 2,6-dinitro-3-methoxy-5-acetylaminobenzoate 

Relevant articles and documents

Discovery of (3-Benzyl-5-hydroxyphenyl)carbamates as new antitubercular agents with potent in vitro and in vivo efficacy

A series of 3-amino-5-benzylphenol derivatives were designed and synthesized. Among them, (3-benzyl-5-hydroxyphenyl)carbamates were found to exert good inhibitory activity against M. tuberculosis H37Ra, H37Rv and clinically isolated multidrug-resistant M. tuberculosis strains (MIC = 0.625-6.25 μg/mL). The privileged compounds 3i and 3l showed moderate cytotoxicity against cell line A549. Compound 3l also exhibited potent in vivo inhibitory activity on a mouse infection model via the oral administration. The results demonstrated 3-hydroxyphenylcarbamates as a class of new antitubercular agents with good potential.

Monoenomycin: A simplified trienomycin A analogue that manifests anticancer activity

Macrocyclic natural products are a powerful class of leadlike chemical entities. Despite commonly violating Lipinski's "rule of 5", these compounds often demonstrate superior druglike physicochemical and pharmacokinetic attributes when compared to their acyclic counterparts. However, the elaborate structural architectures of such molecules require rigorous synthetic investigation that complicates analogue development and their application to drug discovery programs. To circumvent these limitations, a conformation-based approach using limited structure-activity relationships and molecular modeling was implemented to design simplified analogues of trienomycin A, in which the corresponding analogues could be prepared in a succinct manner to rapidly identify essential structural components necessary for biological activity. Trienomycin A is a member of the ansamycin family of natural products that possesses potent anticancer activity. These studies revealed a novel trienomycin A analogue, monoenomycin, which manifests potent anticancer activity.

(3-HYDROXY-4-AMINO-BUTAN-2-YL) -3- (2-THIAZOL-2-YL-PYRROLIDINE-1-CARBONYL) BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS BETA-SECRETASE INHIBITORS FOR TREATING

The present invention provides novel beta-secretase inhibitors and methods for their use, including methods of treating of Alzheimer's disease. (Formula)