78281-61-5 Usage
Description
2-Amino-3-benzoyl-alpha-(methylthio)benzeneacetamide is a chemical compound that serves as an impurity in Nepafenac (N390080), a non-steroidal anti-inflammatory drug (NSAID) with analgesic properties. It is characterized by its selective inhibition of the COX-2 enzyme, which plays a crucial role in the inflammation process.
Uses
Used in Pharmaceutical Industry:
2-Amino-3-benzoyl-alpha-(methylthio)benzeneacetamide is used as an impurity in the production of Nepafenac (N390080) for its anti-inflammatory and analgesic effects. 2-Amino-3-benzoyl-alpha-(methylthio)benzeneacetamide contributes to the overall efficacy of Nepafenac as a selective COX-2 inhibitor, helping to reduce inflammation and alleviate pain without causing the side effects typically associated with non-selective NSAIDs.
As an impurity in Nepafenac, 2-Amino-3-benzoyl-alpha-(methylthio)benzeneacetamide may also play a role in the drug's pharmacological activity, potentially enhancing its therapeutic effects or modifying its pharmacokinetic properties. However, it is essential to monitor and control the levels of this impurity to ensure the safety and efficacy of the final drug product.
Check Digit Verification of cas no
The CAS Registry Mumber 78281-61-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,8,2,8 and 1 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 78281-61:
(7*7)+(6*8)+(5*2)+(4*8)+(3*1)+(2*6)+(1*1)=155
155 % 10 = 5
So 78281-61-5 is a valid CAS Registry Number.
InChI:InChI=1/C16H16N2O2S/c1-21-15(16(18)20)12-9-5-8-11(13(12)17)14(19)10-6-3-2-4-7-10/h2-9,15H,17H2,1H3,(H2,18,20)
78281-61-5Relevant articles and documents
Preparation method of high-purity nepafenac intermediate
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Paragraph 0049-0083, (2021/05/15)
The invention provides a preparation method of a high-purity nepafenac intermediate, which belongs to the technical field of medicine synthesis. The preparation method comprises the following steps of dissolving a chlorinating agent in an organic solvent,
PROCESS FOR THE PREPARATION OF NEPAFENAC
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Page/Page column 13; 14, (2015/01/16)
Described herein are processes for the preparation of nepafenac and related intermediates, particularly wherein 2-aminobenzophenone is treated with a 2-(alkylthio)acetamide in the presence of sulfuryl chloride to afford a 2-(2-amino-3-benzoylphenyl)-2-(alkylthio)acetamide, which upon reduction affords nepafenac. Described herein are also processes for the purification of nepafenac, particularly for the removal of structurally similar impurities.
Process For Preparing A Benzoylbenzeneacetamide Derivative
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Page/Page column 4-5, (2009/12/27)
Disclosed is a process for preparing anti-inflammatory compound nepafenac comprising preparing a compound of formula (V) wherein a N-halosuccinimide is used as the halogenating agent, followed by desulfurization using Raney Nickel. Also disclosed is a polymorphic form B of 2-amino-3-benzoyl-α-(methylthio)-benzeneacetamide (i.e., a compound of formula (V) wherein R is methyl