78329-47-2

Basic information

• Product Name: 5-Chloro-1-(phenylsulfonyl)indole
• Synonyms: 5-Chloro-1-(phenylsulfonyl)indole
• CAS NO: 78329-47-2
• Molecular Formula: C₁₄H₁₀ClNO₂S
• Molecular Weight: 291.7527
• Mol File: 78329-47-2.mol
• Article Data: 17

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-Chloro-1-(phenylsulfonyl)indole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloro-1-(phenylsulfonyl)indole(78329-47-2)
• EPA Substance Registry System: 5-Chloro-1-(phenylsulfonyl)indole(78329-47-2)

Safety Data

• Hazardous Substances Data: 78329-47-2(Hazardous Substances Data)

Upstream product

• 17422-32-1 5-chloro-1H-indole 
• 98-09-9 benzenesulfonyl chloride 
• 1073-69-4 N-4-chlorophenylhydrazine 

Downstream Products

• 78329-49-4 (E)-5-chloro-2-(1-phenylprop-1-en-1-yl)-1H-indole 
• 181299-29-6 1-benzenesulfonyl-5-chloro-2-methyl-1H-indole 
• 615552-47-1 1-benzenesulfonyl-5-chloro-1H-indole-2-carbaldehyde 
• 249292-35-1 5-chloro-1-phenyl-sulfonylindole-2-sulfonyl chloride 
• 896137-91-0 (5-chloro-1-phenylsulfonyl-1H-indol-2-yl)-(5-methoxy-1-phenylsulfonyl-1H-indol-2-yl)methanone 
• 259808-17-8 1-[(5-chloro-1-phenylsulfonylindol-2-yl)sulfonyl]-3-(2-methylpropyl)piperazine 
• 249292-02-2 1-(5-chloroindol-2-ylsulfonyl)4-[4-(pyridin-4-yl)benzoyl]piperazine 
• 259807-33-5 1-(tert-butoxycarbonyl)-4-[(5-chloro-1-phenylsulfonylindol-2-yl)sulfonyl]piperazine 
• 259802-91-0 1-[(5-chloroindol-1-phenylsulfonyl-2-yl)sulfonyl]-4-[4-(4-pyridyl)benzoyl]piperazine 
• 615552-49-3 5-chloro-1-benzenesulfonyl-2-(5'-chloroindol-2'-yl)indole 
• 615552-48-2 2-[trans-2-(5-chloro-2-nitrophenyl)vinyl]-5-chloro-1-(phenylsulfonyl)-1H-indole 
• 1075-35-0 5-chloro-2-methylindole 
• 78329-53-0 5-Chloro-3-formyl-2-(1-phenyl-1-propenyl)indole 
• 78329-51-8 [5-Chloro-2-((E)-1-phenyl-propenyl)-1H-indol-3-yl]-oxo-acetic acid ethyl ester 

Relevant articles and documents

Construction of Oxepino[3,2-b]indoles via [4+3] Annulation of 2-Ylideneoxindoles with Crotonate-Derived Sulfur Ylides

A [4+3] annulation of 2-ylideneoxindoles with crotonate-derived sulfur ylides has been developed. A series of oxepino[3,2-b]indoles were prepared in moderate to excellent yields (62-93%) under mild conditions. Moreover, the synthetic oxepino[3,2-b] indoles can be further transformed into more complex cyclopropa[5,6]oxepino[3,2-b]indoles via a [2+1] cyclopropanation. In addition, the synthetic compounds show certain antiproliferative activity against K562 and MCF-7 cells, and its IC50 values for these two kinds of tumor cells up to 5.40±0.88 μM and 18.41±0.50 μM, respectively. (Figure presented.).

Highly diastereoselective synthesis of cyclopropane-fused spiro-pseudoindoxyl derivatives through [2 + 1] annulation of 2-ylideneoxindoles and sulfonium bromides

Compared with the intensively studied C3 spirooxindoles, limited reliable approaches are reported for synthesizing structurally analogous C2-spiropseudoindoxyl derivatives. Here, we developed an efficient method for highly diastereoselective synthesis of

Development of indole sulfonamides as cannabinoid receptor negative allosteric modulators

Existing CB1 negative allosteric modulators (NAMs) fall into a limited range of structural classes. In spite of the theoretical potential of CB1 NAMs, published in vivo studies have generally not been able to demonstrate the expected therapeutically-relevant CB1-mediated effects. Thus, a greater range of molecular tools are required to allow definitive elucidation of the effects of CB1 allosteric modulation. In this study, we show a novel series of indole sulfonamides. Compounds 5e and 6c (ABD1075) had potencies of 4 and 3?nM respectively, and showed good oral exposure and CNS penetration, making them highly versatile tools for investigating the therapeutic potential of allosteric modulation of the cannabinoid system.