78346-78-8

Basic information

• Product Name: Z-L-Ile-L-Glu(OtBu)-OH
• Synonyms: Z-L-Ile-L-Glu(OtBu)-OH
• CAS NO: 78346-78-8
• Molecular Weight: 450.532
• Mol File: 78346-78-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Z-L-Ile-L-Glu(OtBu)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: Z-L-Ile-L-Glu(OtBu)-OH(78346-78-8)
• EPA Substance Registry System: Z-L-Ile-L-Glu(OtBu)-OH(78346-78-8)

Safety Data

• Hazardous Substances Data: 78346-78-8(Hazardous Substances Data)

Upstream product

• 7763-16-8 N²-benzyloxycarbonyl-L-glutamine-(4-nitro-phenyl ester) 
• 3391-99-9 N-Z-L-isoleucine N-hydroxysuccinimide ester 
• 2419-56-9 L-glutamic acid 5-tert-butyl ester 

Downstream Products

• 151990-38-4 Z-L-Glu(OtBu)-L-Thr(tBu)-L-Ile-L-Glu(OtBu)-OH 
• 151990-36-2 Z-L-Thr(tBu)-L-Ile-L-Glu(OtBu)-OH 
• 890660-21-6 Cbz-Ile-Glu(OtBu)-Ala-OH 
• 890660-20-5 Cbz-Ile-Glu(OtBu)-OSuc 

Relevant articles and documents

Optimization of subsite binding to the β5 subunit of the human 20S proteasome using vinyl sulfones and 2-keto-1,3,4-oxadiazoles: Syntheses and cellular properties of potent, selective proteasome inhibitors

Beginning with the peptide sequence Cbz-Ile-Glu(OtBu)-Ala-Leu found in PSI (3), a series of vinyl sulfones (VS) were synthesized for evaluation as inhibitors of the chymotrypsin-like activity of the 20S proteasome. Variations at the key P3 position confir

Total Synthesis of Thymosin β4, 3. Conventional Synthesis of the Fragment of Thymosin β4

As part of our total synthesis of thymosin β4, an optimized synthesis of the C-terminal part of thymosin β4 is described.Side chain functional residues of the tridecapeptide are masked by tert-butyl and the α-amino-acids residues are protected by the Z groups.The fully protected peptide derivative was obtained by WSCI/HOBt coupling of three fragments representing the segments , and . Key words: Thymosin β4; fragment ; peptide; solution synthesis; thymosins.