78432-78-7

Basic information

• Product Name: 19-hydroxybaccatin III
• Synonyms: 19-hydroxybaccatin III;7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one,6,12b-bis(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,9,11-trihydroxy-4a-(hydroxymethyl)-8,13,13-trimethyl-,(2aR,4S,4aR,6R,9S,11S,12S,12aR,12bS)-
• CAS NO: 78432-78-7
• Molecular Formula: C₃₁H₃₈O₁₂
• Molecular Weight: 602.63
• Mol File: 78432-78-7.mol
• Article Data: 0

Chemical Properties

• Melting Point: 173-175 °C(Solv: ethanol (64-17-5))
• Boiling Point: 752.1°C at 760 mmHg
• Flash Point: 239.9°C
• Appearance: /
• Density: 1.43g/cm³
• Vapor Pressure: 9.2E-24mmHg at 25°C
• Refractive Index: 1.618
• Storage Temp.: -20°C Freezer
• Solubility: Acetone (Slightly), Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• PKA: 12.66±0.70(Predicted)
• CAS DataBase Reference: 19-hydroxybaccatin III(CAS DataBase Reference)
• NIST Chemistry Reference: 19-hydroxybaccatin III(78432-78-7)
• EPA Substance Registry System: 19-hydroxybaccatin III(78432-78-7)

Safety Data

• Hazardous Substances Data: 78432-78-7(Hazardous Substances Data)

Usage

Description

19-Hydroxybaccatin III is a taxane diterpenoid, a type of natural product derived from the plant species Taxus mairei, which is native to Taiwan. It is structurally similar to the well-known chemotherapy drug paclitaxel and has potential applications in the pharmaceutical industry due to its unique chemical properties.

Uses

Used in Pharmaceutical Industry:
19-Hydroxybaccatin III is used as a starting material for the semi-synthesis of various taxane-based anticancer drugs. Its chemical structure allows for the modification and optimization of existing drugs, potentially improving their efficacy and reducing side effects.
Used in Anticancer Applications:
19-Hydroxybaccatin III is used as an anticancer agent, particularly for the development of new drugs targeting various types of cancer. Its taxane diterpenoid structure has shown promise in disrupting microtubule dynamics, a key process in cell division, leading to the prevention of cancer cell proliferation.
Used in Drug Delivery Systems:
In the field of drug delivery, 19-Hydroxybaccatin III can be used as a component in the development of novel drug carriers and formulations. Its incorporation into drug delivery systems may enhance the bioavailability, targeting, and overall effectiveness of taxane-based chemotherapy treatments.

InChI:InChI=1/C31H38O12/c1-15-19(35)12-31(39)26(42-27(38)18-9-7-6-8-10-18)24-29(13-32,20(36)11-21-30(24,14-40-21)43-17(3)34)25(37)23(41-16(2)33)22(15)28(31,4)5/h6-10,19-21,23-24,26,32,35-36,39H,11-14H2,1-5H3/t19-,20+,21-,23-,24+,26+,29-,30+,31+/m1/s1