78603-95-9 Usage
Description
(S)-(-)-2-AMINO-3-METHYL-1,1-DIPHENYL-1-BUTANOL is a chiral secondary amine with a unique molecular structure featuring a 2-amino group, a 3-methyl group, and two phenyl rings attached to a butanol backbone. (S)-(-)-2-AMINO-3-METHYL-1,1-DIPHENYL-1-BUTANOL is characterized by its specific stereochemistry, with the (S)-configuration, which is crucial for its reactivity and potential applications in various chemical and pharmaceutical processes.
Uses
Used in Pharmaceutical Industry:
(S)-(-)-2-AMINO-3-METHYL-1,1-DIPHENYL-1-BUTANOL is used as a chiral building block for the synthesis of various pharmaceutical compounds. Its unique structure and stereochemistry make it a valuable intermediate in the development of enantiomerically pure drugs, which can exhibit improved efficacy and reduced side effects compared to their racemic counterparts.
Used in Organic Synthesis:
(S)-(-)-2-AMINO-3-METHYL-1,1-DIPHENYL-1-BUTANOL is used as a versatile intermediate in organic synthesis for the preparation of a wide range of organic compounds, including amino alcohols, chiral ligands, and catalysts. Its reactivity and functional groups allow for various chemical transformations, making it a useful component in the synthesis of complex organic molecules.
Used in Chiral Pool Synthesis:
(S)-(-)-2-AMINO-3-METHYL-1,1-DIPHENYL-1-BUTANOL is used as a chiral source in chiral pool synthesis, a strategy that involves the use of chiral compounds as starting materials to synthesize enantiomerically pure target molecules. Its unique stereochemistry and functional groups make it a valuable building block for the preparation of chiral compounds with potential applications in various industries, such as pharmaceuticals, agrochemicals, and fragrances.
Check Digit Verification of cas no
The CAS Registry Mumber 78603-95-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,8,6,0 and 3 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 78603-95:
(7*7)+(6*8)+(5*6)+(4*0)+(3*3)+(2*9)+(1*5)=159
159 % 10 = 9
So 78603-95-9 is a valid CAS Registry Number.
InChI:InChI=1/C17H21NO/c1-13(2)16(18)17(19,14-9-5-3-6-10-14)15-11-7-4-8-12-15/h3-13,16,19H,18H2,1-2H3/t16-/m0/s1
78603-95-9Relevant articles and documents
Simple primary β-amino alcohols as organocatalysts for the asymmetric Michael addition of β-keto esters to nitroalkenes
Begum, Zubeda,Sannabe, Haruka,Seki, Chigusa,Okuyama, Yuko,Kwon, Eunsang,Uwai, Koji,Tokiwa, Michio,Tokiwa, Suguru,Takeshita, Mitsuhiro,Nakano, Hiroto
, p. 203 - 209 (2021/02/09)
Simple primary β-amino alcohols act as an efficient organocatalysts in the asymmetric Michael addition of β-keto esters with nitroalkenes affording highly pure chiral Michael adducts. Also, both enantiomers of the adducts were obtained, depending on the specific catalyst used and reaction temperature.
Catalytic intramolecular hydroamination of aminoallenes using titanium complexes of chiral, tridentate, dianionic imine-diol ligands
Sha, Fanrui,Mitchell, Benjamin S.,Ye, Christopher Z.,Abelson, Chase S.,Reinheimer, Eric W.,Lemagueres, Pierre,Ferrara, Joseph D.,Takase, Michael K.,Johnson, Adam R.
, p. 9603 - 9616 (2019/07/09)
Alkylation of d- or l-phenylalanine or valine alkyl esters was carried out using methyl or phenyl Grignard reagents. Subsequent condensation with salicylaldehyde, 3,5-di-tert-butylsalicylaldehyde, or 5-fluorosalicylaldehyde formed tridentate, X2/sub
NeoPHOX - A structurally tunable ligand system for asymmetric catalysis
Padevět, Jaroslav,Schrems, Marcus G.,Scheil, Robin,Pfaltz, Andreas
supporting information, p. 1185 - 1195 (2016/07/06)
A synthesis of new NeoPHOX ligands derived from serine or threonine has been developed. The central intermediate is a NeoPHOX derivative bearing a methoxycarbonyl group at the stereogenic center next to the oxazoline N atom. The addition of methylmagnesiu