78646-17-0 Usage
Description
2-HYDROXYBENZOIC-3,4,5,6-D4 ACID, also known as Labelled Salicylic Acid, is a compound commonly used as an internal standard in various analytical techniques such as LC/MS and GC/MS. It is suitable for applications in clinical and diagnostic testing, pharmaceutical research, phytochemical testing, and isotope dilution methods. 2-HYDROXYBENZOIC-3,4,5,6-D4 ACID is a deuterated version of Salicylic Acid, which is the major metabolite of aspirin and a phytohormone found in plants with roles in plant growth and development, photosynthesis, transpiration, ion uptake, and transport. It is a white solid in its chemical form.
Uses
Used in Pharmaceutical Research:
2-HYDROXYBENZOIC-3,4,5,6-D4 ACID is used as an internal standard for various LC/MS and GC/MS applications in pharmaceutical research. It helps in the accurate quantification and identification of compounds, ensuring the reliability of the results.
Used in Clinical and Diagnostic Testing:
In the field of clinical and diagnostic testing, 2-HYDROXYBENZOIC-3,4,5,6-D4 ACID is used as an internal standard to improve the accuracy and precision of test results, leading to better diagnosis and treatment of various medical conditions.
Used in Phytochemical Testing:
2-HYDROXYBENZOIC-3,4,5,6-D4 ACID is used as an internal standard in phytochemical testing to analyze the chemical composition of plant extracts and identify bioactive compounds. This helps in the discovery of new drugs and understanding the pharmacological properties of plant-based medicines.
Used in Isotope Dilution Methods:
In isotope dilution methods, 2-HYDROXYBENZOIC-3,4,5,6-D4 ACID is used as an internal standard to accurately measure the concentration of target compounds in complex samples. This technique is widely used in environmental, forensic, and clinical chemistry for the determination of trace elements and contaminants.
Used in the Analysis of Acetylsalicylic Acid Impurities:
2-HYDROXYBENZOIC-3,4,5,6-D4 ACID is used as an internal standard for the analysis of impurities in Acetylsalicylic Acid (Aspirin), such as Labelled Salicylic Acid (S088125) and Labelled Acetylsalicylic Acid EP Impurity C. This helps in ensuring the quality and purity of the final product, which is crucial for its safety and efficacy.
Check Digit Verification of cas no
The CAS Registry Mumber 78646-17-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,8,6,4 and 6 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 78646-17:
(7*7)+(6*8)+(5*6)+(4*4)+(3*6)+(2*1)+(1*7)=170
170 % 10 = 0
So 78646-17-0 is a valid CAS Registry Number.
InChI:InChI=1/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10)/i1D,2D,3D,4D
78646-17-0Relevant articles and documents
Efficient continuous-flow HD exchange reaction of aromatic nuclei in D2O/2-PrOH mixed solvent in a catalyst cartridge packed with platinum on carbon beads
Park, Kwihwan,Ito, Naoya,Yamada, Tsuyoshi,Sajiki, Hironao
supporting information, p. 600 - 605 (2021/03/29)
Herein, a continuous-flow deuteration methodology for various aromatic compounds is developed based on heterogeneous platinum-catalyzed hydrogen-deuterium exchange. The reaction entails the transfer of a substrate dissolved in a mixed solvent of 2-propanol and deuterium oxide into a catalyst cartridge packed with platinum on carbon beads (Pt/CB). Pt/ CB could be continuously used without significant deterioration of catalyst activity for at least 24 h. Deuteration proceeded within 60 s of the substrate solutions being passed through the Pt/CB layer in the Pt/CB-packed cartridge.
Preparation and analysis of deuterium-labeled aspirin: Application to pharmacokinetic studies
Pedersen,FitzGerald
, p. 188 - 192 (2007/10/02)
Inhibition of endogenous prostacyclin and thromboxane biosynthesis by aspirin is critically dose-dependent in humans. Gastrointestinal and hepatic hydrolysis may limit systemic availability of aspirin, especially in low doses, perhaps contributing to the
