78702-61-1

Basic information

• Product Name: 2-bis(dimethylamino)phosphinoyl-1-benzyl-1,2,3,4-tetrahydroisoquinoline
• Synonyms: 2-bis(dimethylamino)phosphinoyl-1-benzyl-1,2,3,4-tetrahydroisoquinoline
• CAS NO: 78702-61-1
• Molecular Weight: 357.436
• Mol File: 78702-61-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-bis(dimethylamino)phosphinoyl-1-benzyl-1,2,3,4-tetrahydroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bis(dimethylamino)phosphinoyl-1-benzyl-1,2,3,4-tetrahydroisoquinoline(78702-61-1)
• EPA Substance Registry System: 2-bis(dimethylamino)phosphinoyl-1-benzyl-1,2,3,4-tetrahydroisoquinoline(78702-61-1)

Safety Data

• Hazardous Substances Data: 78702-61-1(Hazardous Substances Data)

Upstream product

• 100-44-7 benzyl chloride 
• 78702-53-1 2-bis(dimethylamino)phosphinoyl-1,2,3,4-tetrahydroisoquinoline 
• 91-21-4 1,2,3,4-tetrahydroisoquinoline 
• 76068-81-0 1-(3,4-dihydroisoquinolin-2(1H)-yl)-2,2-dimethylpropan-1-one 

Downstream Products

• 19716-56-4 1-benzyl-1,2,3,4-tetrahydroisoquinoline 

Relevant articles and documents

ALKYLATION OF THE ISOQUINOLINE SKELETON IN THE 1-POSITION: LITHIATED 2-PIVALOYL- AND 2-BIS(DIMETHYLAMINO)-PHOSPHINOYL-1,2,3,4-TETRAHYDROISOQUINOLINES

Nucleophilic reactivity in the 1-position of 1,2,3,4-tetrahydroisoquinoline is generated by lithiation of the N-pivaloyl- (16a) and N-phosphinoyl-derivatives (17a).The organolithium compounds (16b, 17b) thus obtained are highly nucleophilic and can be alkylated even with poor alkylating reagents such as secondary halides, neopentyl bromide and cyclopentanone.Hydrolysis of the phosphorylamide products with hydrochloric acid leads to 1-substituted tetrahydroisoquinolines in excellent yields (Table 2).