78740-44-0

Basic information

• Product Name: Ethanone, 1-[2,3,4,5-tetramethyl-6-[(nitrooxy)methyl]phenyl]-
• CAS NO: 78740-44-0
• Molecular Formula: C13H17NO4
• Molecular Weight: 251.282
• Mol File: 78740-44-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-[2,3,4,5-tetramethyl-6-[(nitrooxy)methyl]phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-[2,3,4,5-tetramethyl-6-[(nitrooxy)methyl]phenyl]-(78740-44-0)
• EPA Substance Registry System: Ethanone, 1-[2,3,4,5-tetramethyl-6-[(nitrooxy)methyl]phenyl]-(78740-44-0)

Safety Data

• Hazardous Substances Data: 78740-44-0(Hazardous Substances Data)

Upstream product

• 2040-01-9 2',3',4',5',6'-pentamethylacetophenone 
• 4124-31-6 trichloroacetic acid anhydride 

Relevant articles and documents

Positional Reactivity of Acylpolymethylbenzenes in Electrophilic Substitution

Friedel-Crafts acylation, bromination, deuteration, and nitration of acetylpentamethylbenzene (APMB), 1-acetyl-2,3,4,6-tetramethylbenzene (ATMB), and 1-benzoyl-2,3,4,6-tetramethylbenzene (BTMB) and the resulting product distribution were investigated.Friedel-Crafts acylation, bromination, and deuteration of APMB and Friedel-Crafts acylation of ATMB gave deacetylation-substitution products.On the other hand, bromination and deuteration of ATMB (or BTMB) and Friedel-Crafts acylation of BTMB gave 5-substituted products.In both cases, the positional reactivities were in accordance with the relative ?-complex stability.Conversely, except for Friedel-Crafts-type nitration, the positional reactivities in the nitration of these substrates were strikingly different from those of the above three reactions.Thus, side-chain functionalization at the 6-methyl group occurred in nitration with fuming nitric acid, depending on the solvents in use.The NMDO calculations and the reaction of APMB with single-electron transfer reagents such as tetranitromethane-hν or cerium(IV) ammonium nitrate suggest that the product distribution in nitration can be explained in terms of a single-electron transfer mechanism.

Regioselective Side-Chain Nitration of Polymethylbenzenes Directed by an Acyl Function and Its Application to the Synthesis of Polysubstituted Phthalic Acid Derivatives

Nitration of three types of tetramethylacetophenones and pentamethylacetophenone with fuming nitric acid in acetic anhydride was carried out.The product distributions were compared with those estimated from substituent effects.A variety of acylpentamethylbenzenes including pentamethylbenzoic acid were reacted with the nitrating system to give regioselectively 2-(nitromethyl)-3,4,5,6-tetramethylacylbenzenes.The selective nitrations of some benzoic acid derivatives followed by an alkaline treatment have been found to provide the N-hydroxyphthalimide derivatives, which a re readily converted to the phthalic anhydrides and the phthalazines.