78922-82-4Relevant articles and documents
A rapid reaction releasing the carboxyl terminal residues of peptides
Yagisawa, Shiroki,Urakami, Masako
, p. 7557 - 7560 (1996)
Alcoholysis of peptide oxazolones in alcohols containing dilute acid, such as 0.02M HCl, gives the C-terminal amino acid and the ester of the shortened peptide within 10 minutes at room temperature in 30-70% yields. This together with the finding that the peptide oxazolones can be formed within 3 minutes with alkylchloroformates enables the rapid removal of peptide C-terminal residues.
