790667-43-5

Basic information

• Product Name: 1-Piperidinecarboxylicacid,2-methyl-4-oxo-,1,1-dimethylethylester,(2R)-(9CI)
• Synonyms: 1-Piperidinecarboxylicacid,2-methyl-4-oxo-,1,1-dimethylethylester,(2R)-(9CI);(2R)-2-Methyl-4-oxo-piper...;(2R)-2-Methyl-4-oxo-piperidine-1-carboxylic acid tert-butyl ester;1-N-boc-2(R)-Methyl-piperidin-4-one;tert-butyl (2R)-2-methyl-4-oxopiperidine-1-carboxylate;1-Piperidinecarboxylic acid, 2-methyl-4-oxo-, 1,1-dimethylethyl ester, (2R)-;(R)-tert-butyl 2-methyl-4-oxopiperidine-1-carboxylate;(R)-2-Methyl-4-oxopiperidine-1-carboxylic acid tert-butyl ester
• CAS NO: 790667-43-5
• Molecular Formula: C₁₁H₁₉NO₃
• Molecular Weight: 213.28
• Product Categories: METHYL
• Mol File: 790667-43-5.mol
• Article Data: 5

Chemical Properties

• Melting Point: 57.7 °C
• Boiling Point: 298.8±33.0 °C(Predicted)
• Appearance: /
• Density: 1.060±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.52±0.40(Predicted)
• CAS DataBase Reference: 1-Piperidinecarboxylicacid,2-methyl-4-oxo-,1,1-dimethylethylester,(2R)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidinecarboxylicacid,2-methyl-4-oxo-,1,1-dimethylethylester,(2R)-(9CI)(790667-43-5)
• EPA Substance Registry System: 1-Piperidinecarboxylicacid,2-methyl-4-oxo-,1,1-dimethylethylester,(2R)-(9CI)(790667-43-5)

Safety Data

• Hazardous Substances Data: 790667-43-5(Hazardous Substances Data)

Usage

General Description

1-Piperidinecarboxylicacid,2-methyl-4-oxo-,1,1-dimethylethylester,(2R)-(9CI) is also known by its chemical formula as tert-butyl 2-methyl-4-oxo-1-piperidinecarboxylate. It is an ester derivative of piperidinecarboxylic acid and is commonly used in the pharmaceutical industry as a building block for the synthesis of various drugs and drug candidates. This chemical compound is useful in the preparation of potential HIV protease inhibitors and is also used as a precursor for the synthesis of various bioactive compounds. It is important to handle this chemical with caution as it can be harmful if ingested or inhaled and can cause skin and eye irritation.

Upstream product

• 71322-99-1 2-methyl-4-oxopiperidine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 190906-92-4 tert-butyl 2-methyl-4-oxopiperidine-1-carboxylate 
• 325486-45-1 tert-butyl 4-oxo-3,4-dihydropyridine-1(2H)-carboxylate 
• 75-24-1 trimethylaluminum 
• 89467-37-8 (R)-2-methyl-1-((S)-1-phenylethyl)piperidin-4-one 

Downstream Products

• 850083-76-0 (2R,4R)-4-(3-(2-chloro-4-fluoro-benzoylamino)-phenylamino)-2-methyl-piperidine-1-carboxylic acid tert-butyl ester 
• 790667-44-6 tert-butyl (2R,4R)-4-hydroxy-2-methylpiperidine-1-carboxylate 
• 790668-06-3 (2R,4S)-tert-butyl 4-hydroxy-2-methylpiperidine-1-carboxylate 
• 1691250-97-1 (2R)-tert-butyl 4-amino-2-methylpiperidine-1-carboxylate 
• 152491-46-8 tert-butyl (2R)-4-hydroxy-2-methylpiperidine-1-carboxylate 

Relevant articles and documents

N-SUBSTITUTED TETRAHYDROTHIENOPYRIDINE DERIVATIVES AND USES THEREOF

A compound of Formula (I) is provided that has been shown to be useful for treating a disease caused by a viral infection: (I) wherein R1, R2, R3, A, L, m, n, p and q are as defined herein.

Catalytic asymmetric synthesis of the alkaloid (+)-myrtine

A new protocol for the asymmetric synthesis of trans-2,6-disubstituted-4- piperidones has been developed using a catalytic enantioselective conjugate addition reaction in combination with a diastereoselective lithiation- substitution sequence; an efficient synthesis of (+)-myrtine has been achieved via this route.

(PIPERIDINYLOXY)PHENYL, (PIPERIDINYLOXY)PYRIDINYL, (PIPERIDINYLSULFANYL)PHENYL AND (PIPERIDINYLSULFANYL)PYRIDINYL COMPOUNDS AS 5-HT1F AGONISTS

The present invention relates to compounds of formula 1: and pharmaceutically acceptable acid addition sails thereof. The compounds of the present invention are useful for activating 5-HTIF receptors, inhibiting neuronal protein extravasation, and for the treatment or preverition of migraine in mammals, particularly humans.