79098-88-7

Basic information

• Product Name: 1-benzyl-4-(1,2,3,4-tetrahydro-2-oxo-3-quinazolinyl)piperidine
• Synonyms: 1-benzyl-4-(1,2,3,4-tetrahydro-2-oxo-3-quinazolinyl)piperidine;3-(1-Benzylpiperidin-4-yl)-1,2,3,4-tetrahydroquinazolin-2-one;3-(1-Benzylpiperidin-4-yl)-3,4-dihydroquinazolin-2(1H)-one
• CAS NO: 79098-88-7
• Molecular Formula: C₂₀H₂₃N₃O
• Molecular Weight: 321.41612
• Mol File: 79098-88-7.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-benzyl-4-(1,2,3,4-tetrahydro-2-oxo-3-quinazolinyl)piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-4-(1,2,3,4-tetrahydro-2-oxo-3-quinazolinyl)piperidine(79098-88-7)
• EPA Substance Registry System: 1-benzyl-4-(1,2,3,4-tetrahydro-2-oxo-3-quinazolinyl)piperidine(79098-88-7)

Safety Data

• Hazardous Substances Data: 79098-88-7(Hazardous Substances Data)

Upstream product

• 79106-75-5 1-benzyl-4-(2-aminophenylmethyl)aminopiperidine*3HCl 
• 530-62-1 1,1'-carbonyldiimidazole 
• 1205-72-7 1-benzyl-4-amino-piperidine dihydrochloride 
• 79098-87-6 1-benzyl-4-(2-nitrophenylmethyl)aminopiperidine*2HCl 
• 552-89-6 2-nitro-benzaldehyde 
• 79099-03-9 2-amino-N-[1-(phenylmethyl)-4-piperidinyl]-benzenemethanamine 
• 29608-05-7 1-(4-aminobenzyl)piperidine 
• 98754-28-0 (1-benzyl-piperidin-4-yl)-(2-nitro-benzyl)-amine 
• 50541-93-0 4-amino-1-benzylpiperidine 
• 83425-16-5 2-amino-N-(1-benzyl-piperidin-4-yl)-benzamide 
• 68790-38-5 2-(tert-butyloxycarbonylamino)benzoic acid 
• 4403-69-4 2-amino-1-benzylamine 

Downstream Products

• 79106-39-1 1-benzoylmethyl-4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidine 
• 85350-64-7 1-(3-oxo-3-phenylpropyl)-4-(1,2,3,4-tetrahydro-2-oxo-3-quinazolinyl)piperidine 
• 79106-43-7 1-(2-Phenyl-2-hydroxyethyl)-4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidine 
• 79106-40-4 1-(3-Chlorobenzoylmethyl)-4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidin 
• 79106-41-5 1-<2-oxo-2-(4-chlorophenyl)ethyl>-4-(1,2,3,4-tetrahydro-2-oxo-3-quinazolinyl)piperidine 
• 85350-65-8 1-(3-phenyl-3-hydroxypropyl)-4-(1,2,3,4-tetrahydro-2-oxo-3-quinazolinyl)piperidine 
• 79106-42-6 1-(4-Methoxybenzoylmethyl)-4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidine 
• 79098-78-5 1-(3,4-dichlorobenzoylmethyl)-4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidine 
• 79106-44-8 1-[2-(3-Chlorophenyl)-2-hydroxyethyl]-4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidine 
• 79106-45-9 1-<2-(4-chlorophenyl)-2-hydroxyethyl>-4-(1,2,3,4-tetrahydro-2-oxo-3-quinazolinyl)piperidine 
• 79106-46-0 1-[2-(4-Methoxyphenyl)-2-hydroxyethyl]-4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidine 
• 79106-27-7 1-(3,4-dimethoxybenzoylmethyl)-4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidine 
• 79106-47-1 1-[2-(3,4-Dichlorophenyl)-2-hydroxyethyl]-4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidine 
• 79106-31-3 1-<2-oxo-2-(3,4-dimethoxyphenyl)-1-methylethyl>-4-(1,2,3,4-tetrahydro-2-oxo-3-quinazolinyl)piperidine 

Relevant articles and documents

NOVEL HETEROCYCLIC COMPOUNDS AND USE THEREOF IN MEDICINE AND IN COSMETICS

The invention relates to novel heterocyclic compounds of general formula (I), as well as their pharmaceutically acceptable salts, and their enantiomers. The invention also relates to the use thereof as a medicinal product, preferably in the prevention and/or treatment of inflammatory diseases with a neurogenic component or use thereof as a cosmetic. The compounds of the present invention act as antagonists of the CGRP-R receptor.

1,2,4 -TRIAZOLES AS ALLOSTERIC MODULATORS OF MGLU5 RECEPTOR ACTIVITY FOR THE TREATMENT OF SCHIZOPHRENIA OF DEMENTIA

This invention relates to compounds of formula (I) their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. A, B, X, R1, R2, R3 have meanings given in the description.

Process for preparing 1- [N2-[3,5-dibromo-N-[[4-(3,4-dihydro-2(1H)-oxoquinazolin-3-yl)-1-piperidinyl]carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyridinyl)-piperazine

The present application relates to a process for preparing the CGRP-antagonist 1-[N2-[3,5-dibromo-N-[[4-(3,4-dihydro-2(1H)-oxoquinazolin-3-yl)-1-piperidinyl]carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyridinyl)-piperazine of formula by means of which this compound can be prepared in large amounts, in high yields and with high purity.