792937-20-3

Basic information

• Product Name: N-benzyl-aloperine
• CAS NO: 792937-20-3
• Molecular Weight: 322.494
• Mol File: 792937-20-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-benzyl-aloperine(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-aloperine(792937-20-3)
• EPA Substance Registry System: N-benzyl-aloperine(792937-20-3)

Safety Data

• Hazardous Substances Data: 792937-20-3(Hazardous Substances Data)

Upstream product

• 56293-29-9 (+)-aloperine 
• 792937-18-9 1-benzyl-2-oxo-6-piperidin-2-yl-1,2,3,4,6,7,8,8a-octahydro-quinoline-8-carboxylic acid methyl ester 
• 792937-19-0 1-benzyl-8-hydroxymethyl-6-piperidin-2-yl-1,2,3,4,6,7,8,8a-octahydro-1H-quinoline 

Downstream Products

• 56293-29-9 (+)-aloperine 

Relevant articles and documents

Discovery and evolution of 12N-substituted aloperine derivatives as anti-SARS-CoV-2 agents through targeting late entry stage

So far, there is still no specific drug against COVID-19. Taking compound 1 with anti-EBOV activity as the lead, fifty-four 12N-substituted aloperine derivatives were synthesized and evaluated for the anti-SARS-CoV-2 activities using pseudotyped virus model. Among them, 8a exhibited the most potential effects against both pseudotyped and authentic SARS-CoV-2, as well as SARS-CoV and MERS-CoV, indicating a broad-spectrum anti-coronavirus profile. The mechanism study disclosed that 8a might block a late stage of viral entry, mainly via inhibiting host cathepsin B activity rather than directly targeting cathepsin B protein. Also, 8a could significantly reduce the release of multiple inflammatory cytokines in a time- and dose-dependent manner, such as IL-6, IL-1β, IL-8 and MCP-1, the major contributors to cytokine storm. Therefore, 8a is a promising agent with the advantages of broad-spectrum anti-coronavirus and anti-cytokine effects, thus worthy of further investigation.