79425-89-1

Basic information

• Product Name: 1,5-Naphthyridine-4-thiol
• Synonyms: 1,5-Naphthyridine-4-thiol
• CAS NO: 79425-89-1
• Molecular Formula: C₈H₆N₂S
• Molecular Weight: 162.21164
• Mol File: 79425-89-1.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,5-Naphthyridine-4-thiol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,5-Naphthyridine-4-thiol(79425-89-1)
• EPA Substance Registry System: 1,5-Naphthyridine-4-thiol(79425-89-1)

Safety Data

• Hazardous Substances Data: 79425-89-1(Hazardous Substances Data)

Usage

Type of compound

Heterocyclic aromatic compound

Structure

Naphthyridine ring with a thiol group attached at the 4th position

Organic synthesis

Building block for constructing more complex molecules

Pharmaceutical properties

Investigated for anti-inflammatory and antioxidant effects

Chemical reactivity

Thiol group makes it suitable for various chemical reactions and applications in medicinal chemistry and drug development

Additional studies

Potential use in materials science, particularly in the construction of supramolecular structures and functional nanomaterials

Upstream product

• 79425-88-0 2-[1,5]Naphthyridin-4-yl-isothiourea; hydrochloride 
• 7689-63-6 4-chloro-1,5-naphthyridine 
• 25063-68-7 2,2-dimethyl-5-[(pyridin-3-ylamino)methylidene]-1,3-dioxane-4,6-dione 
• 5423-54-1 4-hydroxy-1,5-naphthyridine 
• 462-08-8 pyridin-3-ylamine 
• 16795-72-5 4-oxo-1,4-dihydro-1,5-naphthyridine 

Downstream Products

• 79425-93-7 4-Benzylsulfanyl-[1,5]naphthyridine 
• 79425-95-9 4-Phenylmethanesulfonyl-[1,5]naphthyridine 

Relevant articles and documents

INHIBITORS OF RPN11

Candidate compounds for specific inhibition of Rpn11 are represented by Formula 1a where each of R2, R3, R4, R5, R6, and R7 is independently selected from hydrogen (H), substituted and unsubstituted alkyl groups, carboxyl groups, or substituted and unsubstituted carboxyamides.

Discovery of potent and orally bioavailable inhibitors of Human Uric Acid Transporter 1 (hURAT1) and binding mode prediction using homology model

This Letter describes the discovery of a series of potent inhibitors of Human Uric Acid Transporter 1 (hURAT1). Lead generation and optimization via 3D pharmacophore analysis resulted in compound 41. With an IC50 of 33.7 nM, 41 also demonstrated good oral bioavailability in rat (74.8%) and displayed a consistent PK profile across all species tested (rat, dog and monkey).