79499-60-8

Basic information

• Product Name: 2-Bromo-6-amino-6-(2-chlorophenyl)cyclohexanone hydrobromide
• Synonyms: 2-Bromo-6-amino-6-(2-chlorophenyl)cyclohexanone hydrobromide
• CAS NO: 79499-60-8
• Molecular Weight: 383.51
• Mol File: 79499-60-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Bromo-6-amino-6-(2-chlorophenyl)cyclohexanone hydrobromide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-6-amino-6-(2-chlorophenyl)cyclohexanone hydrobromide(79499-60-8)
• EPA Substance Registry System: 2-Bromo-6-amino-6-(2-chlorophenyl)cyclohexanone hydrobromide(79499-60-8)

Safety Data

• Hazardous Substances Data: 79499-60-8(Hazardous Substances Data)

Usage

Uses

2-Amino-6-bromo-2-(2-chlorophenyl)cyclohexanone-d4 Hydrobromide is an isotope labelled intermediate in the synthesis of Ketamine (K165300) metabolites.

Upstream product

• 79499-57-3 (±)-1-((2-chlorophenyl)(imino)methyl)cyclopentan-1-ol 
• 6740-86-9 (1-Bromocyclopentyl)(2-chlorophenyl)methanone 
• 35211-10-0 norketamine 
• 79499-58-4 1-<(2-Chlorophenyl)iminomethyl>cyclopentanol hydrochloride 

Relevant articles and documents

HYDROXYNORKETAMINE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS

Chemical entities of Formula (I): Including enantiomers thereof, wherein R1 has any of the values described herein, and compositions comprising such chemical entities; their preparation; and their use in various methods, including the treatment of depression, pain, cognitive disorders, neurodegenerative disorders, and other neurological and peripheral disorders.

Synthesis of Ketamine Metabolites I and II and Some Anomalous Reactions of 6-Bromoketamine

Two metabolites of the drug ketamine, 2-(2-chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride (1), have been synthesized.They are the N-demethyl compound, metabolite I (13), and the N-demethyl-5,6-dehydro analogue, metabolite II (15).Three bromo ketone derived from ketamine have also been synthesized and their realtive configuration assigned.In addition, attempted dehydrohalogenation of axial 2-bromoketamine (2a) with sodium amide in liquid ammonia has produced a novel entry into the 6-azabicycloheptane ring system.The structure of the rearrangement product (3) has been confirmed by unequivocal synthesis.Other unusual reactions include the reduction of an N-alkylazetidinone to an N-alkylazetidine and an acid-catalyzed N-alkyl cleavage of a β-lactam.