79559-59-4

Basic information

• Product Name: 1,7-Diphenyl-4-hepten-3-one
• Synonyms: 1,7-Diphenyl-4-hepten-3-one
• CAS NO: 79559-59-4
• Molecular Formula: C₁₉H₂₀O
• Molecular Weight: 264.3615
• Mol File: 79559-59-4.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,7-Diphenyl-4-hepten-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1,7-Diphenyl-4-hepten-3-one(79559-59-4)
• EPA Substance Registry System: 1,7-Diphenyl-4-hepten-3-one(79559-59-4)

Safety Data

• Hazardous Substances Data: 79559-59-4(Hazardous Substances Data)

Usage

Physical state

Yellow crystalline solid

Uses

Fragrance and flavor additive in perfumes, soaps, and cosmetics
UV filter in sunscreen
Photoinitiator in the production of adhesives and inks
Key intermediate in the synthesis of pharmaceuticals, dyes, and other organic compounds

Potential concerns

Toxicity
Environmental impact
Ability to bioaccumulate
Disruption of hormone function

Ongoing efforts

Finding alternative chemicals for its various applications due to the mentioned concerns.

Upstream product

• 24192-01-6 5-hydroxy-1,7-diphenylheptan-3-one 
• 3277-89-2 phenethylmagnesium bromide 
• 72134-60-2 (2-Phenethyl-[1,3]dioxolan-2-yl)-acetaldehyde 
• 93559-08-1 (2-Phenethyl-[1,3]dioxolan-2-yl)-acetonitrile 
• 93559-15-0 1-(2-Phenethyl-[1,3]dioxolan-2-yl)-4-phenyl-butan-2-ol 
• 104-53-0 3-phenyl-propionaldehyde 
• 41162-19-0 dimethyl(2-oxo-4-phenylbutyl)phosphonate 
• 501-52-0 3-Phenylpropionic acid 
• 100667-54-7 5-methoxy-1,7-diphenyl-3-heptanone 
• 2021-28-5 ethyl dihydrocinnamate 
• 768-56-9 4-Phenylbut-1-ene 
• 53931-59-2 5-phenyl-1-penten-3-one 
• 103-25-3 3-phenylpropanoic acid methyl ester 
• 645-45-4 hydrocinnamic acid chloride 

Downstream Products

• 1239709-90-0 (3E,5R)-1,7-diphenylhept-3-en-5-ol 
• 87657-76-9 1,7-diphenyl-3-heptanone 

Relevant articles and documents

Diarylheptanoids from the rhizome of Alpinia officinarum HANCE

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GPR52 Antagonist Reduces Huntingtin Levels and Ameliorates Huntington's Disease-Related Phenotypes

GPR52 is an orphan G protein-coupled receptor (GPCR) that has been recently implicated as a potential drug target of Huntington's disease (HD), an incurable monogenic neurodegenerative disorder. In this research, we found that striatal knockdown of GPR52 reduces mHTT levels in adult HdhQ140 mice, validating GPR52 as an HD target. In addition, we discovered a highly potent and specific GPR52 antagonist Comp-43 with an IC50 value of 0.63 μM by a structure-activity relationship (SAR) study. Further studies showed that Comp-43 reduces mHTT levels by targeting GPR52 and promotes survival of mouse primary striatal neurons. Moreover, in vivo study showed that Comp-43 not only reduces mHTT levels but also rescues HD-related phenotypes in HdhQ140 mice. Taken together, our study confirms that inhibition of GPR52 is a promising strategy for HD therapy, and the GPR52 antagonist Comp-43 might serve as a lead compound for further investigation.

Unsaturated ketone compound as well as preparation method and application thereof

The present invention relates to a novel GPR52 antagonist. Specifically, the invention relates to an unsaturated ketone compound, a pharmaceutically acceptable salt, a stereoisomer or a prodrug molecule thereof, and a method for preparing a pharmaceutical composition thereof. The invention further relates to the use of the GPR52 antagonist as an orphan G protein coupled receptor GPR52 antagonist,and further relates to the use of the GPR52 antagonist in the preparation of drugs for preventing and treating Huntington's disease.