799279-19-9

Basic information

• Product Name: 1-Piperidinecarboxylic acid, 4-[1,3-dioxo-3-[3-(phenylmethoxy)phenyl]propyl]-, 1,1-dimethylethyl ester
• CAS NO: 799279-19-9
• Molecular Formula: C26H31NO5
• Molecular Weight: 437.536
• Mol File: 799279-19-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-Piperidinecarboxylic acid, 4-[1,3-dioxo-3-[3-(phenylmethoxy)phenyl]propyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidinecarboxylic acid, 4-[1,3-dioxo-3-[3-(phenylmethoxy)phenyl]propyl]-, 1,1-dimethylethyl ester(799279-19-9)
• EPA Substance Registry System: 1-Piperidinecarboxylic acid, 4-[1,3-dioxo-3-[3-(phenylmethoxy)phenyl]propyl]-, 1,1-dimethylethyl ester(799279-19-9)

Safety Data

• Hazardous Substances Data: 799279-19-9(Hazardous Substances Data)

Upstream product

• 34068-01-4 1-[3-(phenylmethoxy)phenyl]ethan-1-one 
• 293744-38-4 tert-butyl 4-(1H-imindazole-1-carbonyl)piperidine-1-carboxylate 
• 84358-13-4 N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid 

Relevant articles and documents

Synthesis and antibacterial activity of novel and potent DNA gyrase inhibitors with azole ring

The pyrazole, oxazole and imidazole derivatives synthesized in this study exhibited potent antibacterial activity against multidrug resistant Gram-positive bacteria with minimal inhibitory concentration values equivalent to those against susceptible strains. The 4-piperidyl moiety and the pyrazole ring in 1-(3-chlorophenyl)-5-(4-phenoxyphenyl)-3-(4-piperidyl)pyrazole 2, which has previously shown improved DNA gyrase inhibition and target-related antibacterial activity, were transformed to other groups and the in vitro antibacterial activity of the synthesized compounds was evaluated. The selected pyrazole, oxazole and imidazole derivatives showed moderate inhibition against DNA gyrase and topoisomerase IV with similar IC50 values (IC 50 = 9.4-25 μg/mL). In addition, many of the pyrazole, oxazole a1nd imidazole derivatives synthesized in this study exhibited potent antibacterial activity against quinolone-resistant clinical isolates and coumarin-resistant laboratory isolates of Gram-positive bacteria with minimal inhibitory concentration values equivalent to those against susceptible strains.